N²-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-((tert-butoxycarbonyl)amino)ethyl)-L-glutamine

Base Information

• Chemical Name: N²-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-((tert-butoxycarbonyl)amino)ethyl)-L-glutamine
• CAS No.: 1017018-99-3
• Molecular Formula: C₂₆H₃₃N₉O₇
• Molecular Weight: 583.604
• Mol file: 1017018-99-3.mol

Synonyms:N²-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-((tert-butoxycarbonyl)amino)ethyl)-L-glutamine

Chemical Property of N²-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-((tert-butoxycarbonyl)amino)ethyl)-L-glutamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-((tert-butoxycarbonyl)amino)ethyl)-L-glutamine

There total 7 articles about N²-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-((tert-butoxycarbonyl)amino)ethyl)-L-glutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-BOC-1,2-diaminoethane (57260-73-8) + folate (59-30-3) → C26H33N9O7 (1017018-99-3)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.polymer.2010.12.059

Reference yield: 73.0%

N-BOC-1,2-diaminoethane (57260-73-8) + (S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)pentanedioic acid (59-30-3) → N2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzoyl)-N5-(2-((tert-butoxycarbonyl)amino)ethyl)-L-glutamine (1017018-99-3)

Guidance literature:

(S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)pentanedioic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 23 ℃; for 15h;

N-BOC-1,2-diaminoethane; With triethylamine; In dimethyl sulfoxide; at 23 ℃; for 24h;

Reference yield: 69.0%

folic acid (59-30-3) + N-BOC-1,2-diaminoethane (57260-73-8) → C26H33N9O7 (1017018-99-3)

Guidance literature:

folic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; at 20 ℃; for 16h;

N-BOC-1,2-diaminoethane; With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 24h;

DOI:10.1039/c3cc47534d

upstream raw materials:

N-BOC-1,2-diaminoethane

folate

di-tert-butyl dicarbonate

folic acid

Downstream raw materials:

folate-γ-ethylenediamine

C₃₉H₄₄N₁₂O₇

N²-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N⁵-(2-aminoethyl)-L-glutamine