4-Chloro-N-[1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amino}-1-methylsulfanyl-meth-(Z)-ylidene]-benzenesulfonamide

Base Information

Chemical Name:4-Chloro-N-[1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amino}-1-methylsulfanyl-meth-(Z)-ylidene]-benzenesulfonamide
CAS No.:148854-64-2
Molecular Formula:C₁₈H₂₁ClN₄O₆S₂
Molecular Weight:488.973
Hs Code.:

4-Chloro-N-[1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amino}-1-methylsulfanyl-meth-(Z)-ylidene]-benzenesulfonamide

Synonyms:4-Chloro-N-[1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amino}-1-methylsulfanyl-meth-(Z)-ylidene]-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Chloro-N-[1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amino}-1-methylsulfanyl-meth-(Z)-ylidene]-benzenesulfonamide

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Technology Process of 4-Chloro-N-[1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amino}-1-methylsulfanyl-meth-(Z)-ylidene]-benzenesulfonamide

There total 1 articles about 4-Chloro-N-[1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amino}-1-methylsulfanyl-meth-(Z)-ylidene]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13068-12-7
N--4-chlorobenzenesulfonamide

: 25152-20-9
5'-amino-5'-deoxythymidine

: 148854-64-2
4-Chloro-N-[1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amino}-1-methylsulfanyl-meth-(Z)-ylidene]-benzenesulfonamide

Guidance literature:: In pyridine; at 80 ℃; for 18h; Yield given;

Reference yield: 82.0%

: 52450-18-7
3'-amino-3'-deoxythymidine

: 148854-64-2
4-Chloro-N-[1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amino}-1-methylsulfanyl-meth-(Z)-ylidene]-benzenesulfonamide

: 148854-73-3
N'-(p-chlorophenylsulfonyl)-N-(3'-deoxythymidin-3'-yl)-N''-(5'-deoxythymidin-5'-yl)guanidine

Guidance literature:: With silver nitrate; In triethylamine; N,N-dimethyl-formamide; for 18h; Ambient temperature;

Reference yield:

: 148854-64-2
4-Chloro-N-[1-{[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-amino}-1-methylsulfanyl-meth-(Z)-ylidene]-benzenesulfonamide

: 152873-35-3
C₄₈H₅₀ClN₇O₁₂S

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / AgNO₃ / dimethylformamide; triethylamine / 18 h / Ambient temperature

2: 68 percent / pyridine / 18 h / Ambient temperature

With pyridine; silver nitrate; In triethylamine; N,N-dimethyl-formamide;