1-<2-(4-fluorophenyl)-4,4-bis(tosylmethyl)cyclopenten-1-yl>-4-(methylsulfonyl)benzene

Base Information

Chemical Name:1-<2-(4-fluorophenyl)-4,4-bis(tosylmethyl)cyclopenten-1-yl>-4-(methylsulfonyl)benzene
CAS No.:168299-84-1
Molecular Formula:C₃₄H₃₃FO₈S₃
Molecular Weight:684.828
Hs Code.:

Synonyms:1-<2-(4-fluorophenyl)-4,4-bis(tosylmethyl)cyclopenten-1-yl>-4-(methylsulfonyl)benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<2-(4-fluorophenyl)-4,4-bis(tosylmethyl)cyclopenten-1-yl>-4-(methylsulfonyl)benzene

Chemical Property:

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Technology Process of 1-<2-(4-fluorophenyl)-4,4-bis(tosylmethyl)cyclopenten-1-yl>-4-(methylsulfonyl)benzene

There total 13 articles about 1-<2-(4-fluorophenyl)-4,4-bis(tosylmethyl)cyclopenten-1-yl>-4-(methylsulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 168299-81-8
1-<2-(4-fluorophenyl)-4,4-bis(hydroxymethyl)cyclopenten-1-yl>-4-(methylsulfonl)benzene

: 168299-84-1
1-<2-(4-fluorophenyl)-4,4-bis(tosylmethyl)cyclopenten-1-yl>-4-(methylsulfonyl)benzene

Guidance literature:: With pyridine; at 0 ℃;
DOI:10.1021/jm00049a005

Reference yield:

: 2-(4-fluorophenyl)-3-<4-(methylsulfonyl)phenyl>-1,4-dichloro-2-butene

: 168299-84-1
1-<2-(4-fluorophenyl)-4,4-bis(tosylmethyl)cyclopenten-1-yl>-4-(methylsulfonyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / lithium hydride / dimethylformamide / 19 h

2: DIBAL / tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) RT, overnight

3: pyridine / Ambient temperature

With pyridine; lithium hydride; diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm950664x

Reference yield:

: 50413-24-6
2-bromo-1-(4-methanesulfonylphenyl)ethanone

: 168299-84-1
1-<2-(4-fluorophenyl)-4,4-bis(tosylmethyl)cyclopenten-1-yl>-4-(methylsulfonyl)benzene

Guidance literature:: Multi-step reaction with 7 steps

1: 68 percent / triethylamine / acetonitrile / 0.5 h / Ambient temperature

2: 94 percent / triethylamine, p-toluenesulfonic acid, 4 Angstroem molecular sieves / acetonitrile / 16 h / Heating

3: 3.8 g / DIBAL / tetrahydrofuran / 1.) -78 deg C, 20 min, 2.) RT, overnight

4: thionyl chloride / dimethylformamide / 1.) 5 deg C, 22 h, 2.) RT, 8 h

5: 34 percent / lithium hydride / dimethylformamide / 19 h

6: DIBAL / tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) RT, overnight

7: pyridine / Ambient temperature

With pyridine; thionyl chloride; 4 A molecular sieve; lithium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950664x