2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)-10-deacetylbaccatin

Base Information

Chemical Name:2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)-10-deacetylbaccatin
CAS No.:925211-29-6
Molecular Formula:C₂₉H₃₅FO₁₀
Molecular Weight:565.565
Hs Code.:

Synonyms:2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)-10-deacetylbaccatin

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Chemical Property of 2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)-10-deacetylbaccatin

Chemical Property:

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Technology Process of 2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)-10-deacetylbaccatin

There total 6 articles about 2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)-10-deacetylbaccatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)-1-dimethylsilyl-7,10,13-tris(triethylsilyl)-10-deacetylbaccatin

: 925211-29-6
2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)-10-deacetylbaccatin

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/ja0656604

Reference yield:

: 245657-91-4
2-debenzoyl-2-(p-fluorobenzoyl)-7,10,13-tris(triethylsilyl)-10-deacetylbaccatin

: 925211-29-6
2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)-10-deacetylbaccatin

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / imidazole / dimethylformamide / 1 h / 20 °C

2: 66 percent / LHMDS / tetrahydrofuran / 3 h / 0 °C

3: 88 percent / HF*pyridine / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; pyridine hydrogenfluoride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0656604

Reference yield:

: 925211-27-4
2-debenzoyl-2-(p-fluorobenzoyl)-1-dimethylsilyl-7,10,13-tri(triethylsilyl)-10-deacetylbaccatin

: 925211-29-6
2-debenzoyl-2-(p-fluorobenzoyl)-4-deacetyl-4-(d3-acetyl)-10-deacetylbaccatin

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / LHMDS / tetrahydrofuran / 3 h / 0 °C

2: 88 percent / HF*pyridine / tetrahydrofuran / 2 h / 20 °C

With pyridine hydrogenfluoride; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/ja0656604