(1S,2S)-2-(aminomethyl)-N-(2-((S)-2-((1S,2S)-2-(aminomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide

Base Information

Chemical Name:(1S,2S)-2-(aminomethyl)-N-(2-((S)-2-((1S,2S)-2-(aminomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide
CAS No.:1073176-55-2
Molecular Formula:C₂₂H₃₁F₃N₄O₃
Molecular Weight:456.508
Hs Code.:

(1S,2S)-2-(aminomethyl)-N-(2-((S)-2-((1S,2S)-2-(aminomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide

Synonyms:(1S,2S)-2-(aminomethyl)-N-(2-((S)-2-((1S,2S)-2-(aminomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide

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Chemical Property of (1S,2S)-2-(aminomethyl)-N-(2-((S)-2-((1S,2S)-2-(aminomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide

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Technology Process of (1S,2S)-2-(aminomethyl)-N-(2-((S)-2-((1S,2S)-2-(aminomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide

There total 1 articles about (1S,2S)-2-(aminomethyl)-N-(2-((S)-2-((1S,2S)-2-(aminomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1073176-38-1
(1S,2S)-2-(azidomethyl)-N-(2-((S)-2-((1S, 2S)-2-(azidomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide

: 1073176-55-2
(1S,2S)-2-(aminomethyl)-N-(2-((S)-2-((1S,2S)-2-(aminomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: With hydrogen; palladium; In ethanol; for 0.5h; Inert atmosphere;
DOI:10.1002/anie.200802648

Reference yield: 65.0%

: 1073176-57-4
(1S, 2S)-2-(azidomethyl)cyclopropanecarboxylic acid

: 1073176-55-2
(1S,2S)-2-(aminomethyl)-N-(2-((S)-2-((1S,2S)-2-(aminomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide

: 3282-30-2
pivaloyl chloride

: 1073176-40-5
(1S,2S)-2-(azidomethyl)-N-(((1S,2S)-2-(2-((S)-2-((1S,2S)-2-(((1S,2S)-2-(azidomethyl)cyclopropanecarboxamido)methyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenylcarbamoyl)cyclopropyl)methyl)cyclopropanecarboxamide

Guidance literature:: (1S, 2S)-2-(azidomethyl)cyclopropanecarboxylic acid; pivaloyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃;

(1S,2S)-2-(aminomethyl)-N-(2-((S)-2-((1S,2S)-2-(aminomethyl)cyclopropanecarboxamido)-3-methylbutoxy)-5-(trifluoromethyl)phenyl)cyclopropanecarboxamide; In tetrahydrofuran;
DOI:10.1002/anie.200802648