2(R)-(4-cyclopropylsulfanylphenyl)-3-(2(S),3(S)-diphenyl-1,4-dioxaspiro[4.4]non-7(R)-yl)-N-(2(R)-hydroxy-1(R)-methyl-2-phenylethyl)-N-methylpropionamide

Base Information

• Chemical Name: 2(R)-(4-cyclopropylsulfanylphenyl)-3-(2(S),3(S)-diphenyl-1,4-dioxaspiro[4.4]non-7(R)-yl)-N-(2(R)-hydroxy-1(R)-methyl-2-phenylethyl)-N-methylpropionamide
• CAS No.: 868614-30-6
• Molecular Formula: C₄₁H₄₅NO₄S
• Molecular Weight: 647.879
• Mol file: 868614-30-6.mol

Synonyms:2(R)-(4-cyclopropylsulfanylphenyl)-3-(2(S),3(S)-diphenyl-1,4-dioxaspiro[4.4]non-7(R)-yl)-N-(2(R)-hydroxy-1(R)-methyl-2-phenylethyl)-N-methylpropionamide

Chemical Property of 2(R)-(4-cyclopropylsulfanylphenyl)-3-(2(S),3(S)-diphenyl-1,4-dioxaspiro[4.4]non-7(R)-yl)-N-(2(R)-hydroxy-1(R)-methyl-2-phenylethyl)-N-methylpropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(R)-(4-cyclopropylsulfanylphenyl)-3-(2(S),3(S)-diphenyl-1,4-dioxaspiro[4.4]non-7(R)-yl)-N-(2(R)-hydroxy-1(R)-methyl-2-phenylethyl)-N-methylpropionamide

There total 2 articles about 2(R)-(4-cyclopropylsulfanylphenyl)-3-(2(S),3(S)-diphenyl-1,4-dioxaspiro[4.4]non-7(R)-yl)-N-(2(R)-hydroxy-1(R)-methyl-2-phenylethyl)-N-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7(S)-iodomethyl-2(1S),3(S)-diphenyl-1,4-dioxaspiro[4,4]nonane (868670-98-8) + 2-(4-cyclopropylsulfanyl-phenyl)-N-((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide (868614-28-2) → 2(R)-(4-cyclopropylsulfanylphenyl)-3-(2(S),3(S)-diphenyl-1,4-dioxaspiro[4.4]non-7(R)-yl)-N-(2(R)-hydroxy-1(R)-methyl-2-phenylethyl)-N-methylpropionamide (868614-30-6)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hexamethyldisilazane; In tetrahydrofuran; at -20 - 2 ℃; for 5h;

Reference yield:

ethyl 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetate (745052-94-2) → 2(R)-(4-cyclopropylsulfanylphenyl)-3-(2(S),3(S)-diphenyl-1,4-dioxaspiro[4.4]non-7(R)-yl)-N-(2(R)-hydroxy-1(R)-methyl-2-phenylethyl)-N-methylpropionamide (868614-30-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol / 2 h / 60 °C

2.1: hydrazine / -50 - 80 °C

2.2: 20 h / 100 °C

3.1: pivaloyl chloride; potassium carbonate / acetone / 0.67 h / -10 - 20 °C

3.2: 1.5 h / -15 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -20 - -7 °C

4.2: 4.5 h / -12 - 2 °C

With sodium hydroxide; water; pivaloyl chloride; potassium carbonate; lithium hexamethyldisilazane; hydrazine; In tetrahydrofuran; ethanol; acetone;

Reference yield:

2(R)-(4-cyclopropylsulfanylphenyl)-3-(2(S),3(S)-diphenyl-1,4-dioxaspiro[4.4]non-7(R)-yl)-N-(2(R)-hydroxy-1(R)-methyl-2-phenylethyl)-N-methylpropionamide (868614-30-6) → 2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid (868614-29-3)

Guidance literature:

With sulfuric acid; water; In 1,4-dioxane; for 18h; Heating / reflux;

upstream raw materials:

7(S)-iodomethyl-2(1S),3(S)-diphenyl-1,4-dioxaspiro[4,4]nonane

2-(4-cyclopropylsulfanyl-phenyl)-N-((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-acetamide

ethyl 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetate

Downstream raw materials:

2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid

2(R)-(4-cyclopropylsulfonylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid