2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid

Base Information

Chemical Name:2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid
CAS No.:868614-29-3
Molecular Formula:C₁₇H₂₀O₃S
Molecular Weight:304.41
Hs Code.:

Synonyms:2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid

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Chemical Property of 2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid

Chemical Property:

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Technology Process of 2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid

There total 3 articles about 2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868614-30-6
2(R)-(4-cyclopropylsulfanylphenyl)-3-(2(S),3(S)-diphenyl-1,4-dioxaspiro[4.4]non-7(R)-yl)-N-(2(R)-hydroxy-1(R)-methyl-2-phenylethyl)-N-methylpropionamide

: 868614-29-3
2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid

Guidance literature:: With sulfuric acid; water; In 1,4-dioxane; for 18h; Heating / reflux;

Reference yield:

: 745052-94-2
ethyl 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetate

: 868614-29-3
2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / ethanol / 2 h / 60 °C

2.1: hydrazine / -50 - 80 °C

2.2: 20 h / 100 °C

3.1: pivaloyl chloride; potassium carbonate / acetone / 0.67 h / -10 - 20 °C

3.2: 1.5 h / -15 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -20 - -7 °C

4.2: 4.5 h / -12 - 2 °C

5.1: sulfuric acid; water / 1,4-dioxane / 18 h / Heating / reflux

With sodium hydroxide; sulfuric acid; water; pivaloyl chloride; potassium carbonate; lithium hexamethyldisilazane; hydrazine; In tetrahydrofuran; 1,4-dioxane; ethanol; acetone;

Reference yield:

: 868614-27-1
2-(4-cyclopropylsulfanylphenyl)acetic acid

: 868614-29-3
2(R)-(4-cyclopropylsulfanylphenyl)-3-((R)-3-oxocyclopentyl)propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pivaloyl chloride; potassium carbonate / acetone / 0.67 h / -10 - 20 °C

1.2: 1.5 h / -15 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -20 - -7 °C

2.2: 4.5 h / -12 - 2 °C

3.1: sulfuric acid; water / 1,4-dioxane / 18 h / Heating / reflux

With sulfuric acid; water; pivaloyl chloride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; acetone;