tert-butyl N-(2-hydroxy-3-[isobutyl-(4-nitro-phenylsulfonyl)-amino]-propyl)-carbamate

Base Information

Chemical Name:tert-butyl N-(2-hydroxy-3-[isobutyl-(4-nitro-phenylsulfonyl)-amino]-propyl)-carbamate
CAS No.:447402-84-8
Molecular Formula:C₁₈H₂₉N₃O₇S
Molecular Weight:431.51
Hs Code.:

Synonyms:tert-butyl N-(2-hydroxy-3-[isobutyl-(4-nitro-phenylsulfonyl)-amino]-propyl)-carbamate

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Chemical Property of tert-butyl N-(2-hydroxy-3-[isobutyl-(4-nitro-phenylsulfonyl)-amino]-propyl)-carbamate

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Technology Process of tert-butyl N-(2-hydroxy-3-[isobutyl-(4-nitro-phenylsulfonyl)-amino]-propyl)-carbamate

There total 4 articles about tert-butyl N-(2-hydroxy-3-[isobutyl-(4-nitro-phenylsulfonyl)-amino]-propyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 447402-83-7
tert-butyl N-[2-hydroxy-2-isobutylamino-ethyl]-carbamate

: 447402-84-8
tert-butyl N-(2-hydroxy-3-[isobutyl-(4-nitro-phenylsulfonyl)-amino]-propyl)-carbamate

Guidance literature:: With potassium carbonate; In acetonitrile; for 3h;
DOI:10.1021/jm0208323

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 447402-84-8
tert-butyl N-(2-hydroxy-3-[isobutyl-(4-nitro-phenylsulfonyl)-amino]-propyl)-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / CH₂Cl₂ / 0 - 20 °C

2: mCPBA / CH₂Cl₂ / 36 h / 20 °C

3: methanol / 18 h / 20 °C

4: 90 percent / K₂CO₃ / acetonitrile / 3 h

With methanol; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm0208323

Reference yield:

: 78888-18-3
N-tert-butoxycarbonylprop-2-en-1-amine

: 447402-84-8
tert-butyl N-(2-hydroxy-3-[isobutyl-(4-nitro-phenylsulfonyl)-amino]-propyl)-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: mCPBA / CH₂Cl₂ / 36 h / 20 °C

2: methanol / 18 h / 20 °C

3: 90 percent / K₂CO₃ / acetonitrile / 3 h

With methanol; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm0208323