C₂₀H₂₁Cl₂N₃O₇S

Base Information

Chemical Name:C₂₀H₂₁Cl₂N₃O₇S
CAS No.:1408186-78-6
Molecular Formula:C₂₀H₂₁Cl₂N₃O₇S
Molecular Weight:518.375
Hs Code.:

C<sub>20</sub>H<sub>21</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>7</sub>S

Synonyms:C₂₀H₂₁Cl₂N₃O₇S

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Chemical Property of C₂₀H₂₁Cl₂N₃O₇S

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Technology Process of C₂₀H₂₁Cl₂N₃O₇S

There total 5 articles about C₂₀H₂₁Cl₂N₃O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1408186-61-7
methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-(2,4-dimethoxybenzamido)pyrrolidine-2-carboxylate

: 1408186-78-6
C₂₀H₂₁Cl₂N₃O₇S

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 20 ℃; for 72h;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 114676-47-0,775275-31-5,790644-51-8,754962-86-2
(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester

: 1408186-78-6
C₂₀H₂₁Cl₂N₃O₇S

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0.33 h / 0 - 90 °C / Microwave irradiation

3: sodium hydrogencarbonate / methanol / 0.25 h / 90 °C / Microwave irradiation

4: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5: sodium azide / N,N-dimethyl-formamide / 90 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

7: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

8: hydroxylamine hydrochloride; potassium hydroxide / methanol / 72 h / 20 °C

With dmap; sodium azide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; triphenylphosphine; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 1408186-45-7
methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

: 1408186-78-6
C₂₀H₂₁Cl₂N₃O₇S

Guidance literature:: Multi-step reaction with 7 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0.33 h / 0 - 90 °C / Microwave irradiation

2: sodium hydrogencarbonate / methanol / 0.25 h / 90 °C / Microwave irradiation

3: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: sodium azide / N,N-dimethyl-formamide / 90 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

6: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

7: hydroxylamine hydrochloride; potassium hydroxide / methanol / 72 h / 20 °C

With sodium azide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; triphenylphosphine; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2012.08.028