5-phenylsulfanyl-2-tert-butyl-4-toluene-p-sulfonylhydrazinoquinazoline

Base Information

Chemical Name:5-phenylsulfanyl-2-tert-butyl-4-toluene-p-sulfonylhydrazinoquinazoline
CAS No.:1026678-56-7
Molecular Formula:C₂₅H₂₆N₄O₂S₂
Molecular Weight:478.639
Hs Code.:

Synonyms:5-phenylsulfanyl-2-tert-butyl-4-toluene-p-sulfonylhydrazinoquinazoline

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Chemical Property of 5-phenylsulfanyl-2-tert-butyl-4-toluene-p-sulfonylhydrazinoquinazoline

Chemical Property:

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Technology Process of 5-phenylsulfanyl-2-tert-butyl-4-toluene-p-sulfonylhydrazinoquinazoline

There total 6 articles about 5-phenylsulfanyl-2-tert-butyl-4-toluene-p-sulfonylhydrazinoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 766548-33-8
4-chloro-5-phenylsulfanyl-2-tert-butylquinazoline

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 1026678-56-7
5-phenylsulfanyl-2-tert-butyl-4-toluene-p-sulfonylhydrazinoquinazoline

Guidance literature:: In tetrahydrofuran; Heating;
DOI:10.1016/j.tet.2004.05.059

Reference yield:

: 13182-65-5
2-(tert-butyl)quinazolin-4(3H)-one

: 1026678-56-7
5-phenylsulfanyl-2-tert-butyl-4-toluene-p-sulfonylhydrazinoquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: 37 percent / sBuLi; TMEDA / tetrahydrofuran / 1 h / -78 °C

2: 94 percent / POCl₃; pyridine / chlorobenzene / 5 h / 130 °C

3: 56 percent / tetrahydrofuran / Heating

With pyridine; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; trichlorophosphate; In tetrahydrofuran; chlorobenzene;
DOI:10.1016/j.tet.2004.05.059

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1026678-56-7
5-phenylsulfanyl-2-tert-butyl-4-toluene-p-sulfonylhydrazinoquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 1 h / Heating

1.2: 97 percent / NH₃

2.1: 37 percent / sBuLi; TMEDA / tetrahydrofuran / 1 h / -78 °C

3.1: 94 percent / POCl₃; pyridine / chlorobenzene / 5 h / 130 °C

4.1: 56 percent / tetrahydrofuran / Heating

With pyridine; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; trichlorophosphate; In tetrahydrofuran; chlorobenzene;
DOI:10.1016/j.tet.2004.05.059