2-(4-chlorobenzyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

Base Information

Chemical Name:2-(4-chlorobenzyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde
CAS No.:1310578-70-1
Molecular Formula:C₁₈H₁₁ClFN₃OS
Molecular Weight:371.822
Hs Code.:

Synonyms:2-(4-chlorobenzyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

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Chemical Property of 2-(4-chlorobenzyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

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Technology Process of 2-(4-chlorobenzyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

There total 5 articles about 2-(4-chlorobenzyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1310578-62-1
2-(4-chlorobenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1310578-70-1
2-(4-chlorobenzyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 5 ℃;

2-(4-chlorobenzyl)-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole; In N,N-dimethyl-formamide; at 90 ℃; for 8h; Cooling;
DOI:10.1016/j.ejmech.2011.02.064

Reference yield:

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1310578-70-1
2-(4-chlorobenzyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / 10 - 12 h / Reflux

2: trichlorophosphate; sodium carbonate / 80 - 90 °C

With sodium carbonate; trichlorophosphate; 2: |Vilsmeier Reaction;
DOI:10.1016/j.ejmech.2014.07.054

Reference yield:

: C₉H₁₀ClN₃S

: 1310578-70-1
2-(4-chlorobenzyl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol

2.1: trichlorophosphate / 0 - 5 °C

2.2: 8 h / 80 - 90 °C

With trichlorophosphate; In ethanol; 2.1: |Vilsmeier-Haack Formylation / 2.2: |Vilsmeier-Haack Formylation;
DOI:10.1111/febs.13815