(2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methoxy-amide

Base Information

Chemical Name:(2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methoxy-amide
CAS No.:141964-96-7
Molecular Formula:C₂₁H₃₇NO₅Si
Molecular Weight:411.614
Hs Code.:

Synonyms:(2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methoxy-amide

Suppliers and Price of (2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methoxy-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methoxy-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methoxy-amide

There total 3 articles about (2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methoxy-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 593-56-6
N-methoxylamine hydrochloride

: 141964-94-5
(2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methyl ester

: 141964-96-7
(2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methoxy-amide

Guidance literature:: With trimethylaluminum; In toluene; for 2h; Ambient temperature;
DOI:10.1016/S0040-4039(00)91648-4

Reference yield:

: 81445-44-5
(S)-2-(benzyloxy)propanal

: 141964-96-7
(2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methoxy-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 2) 1N HCl / 1) Pr(fod)3 / 1) CH₂Cl₂, -40 deg C, 2) THF

2: 93 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

3: 82 percent / Me₃Al / toluene / 2 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; trimethylaluminum; (tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octadionato))praseodymium(III); In N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)91648-4

Reference yield:

: 132016-80-9
(2R,3S,4S)-4-Benzyloxy-3-hydroxy-2-((R)-1-hydroxy-ethyl)-pentanoic acid methyl ester

: 141964-96-7
(2S,3S,4S)-4-Benzyloxy-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3-hydroxy-pentanoic acid methoxy-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: 82 percent / Me₃Al / toluene / 2 h / Ambient temperature

With 1H-imidazole; trimethylaluminum; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)91648-4