10-chloromethyl-7-(p-methylphenyl)-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-one

Base Information

• Chemical Name: 10-chloromethyl-7-(p-methylphenyl)-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-one
• CAS No.: 1621314-74-6
• Molecular Formula: C₂₃H₁₇ClN₂O₂
• Molecular Weight: 388.853
• Mol file: 1621314-74-6.mol

Synonyms:10-chloromethyl-7-(p-methylphenyl)-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-one

Chemical Property of 10-chloromethyl-7-(p-methylphenyl)-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-chloromethyl-7-(p-methylphenyl)-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-one

There total 3 articles about 10-chloromethyl-7-(p-methylphenyl)-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-chloro-N-(3-cyano-4-(p-methylphenyl)-4H-benzo[h]chromen-2-yl)acetamide (1621314-58-6) → 10-chloromethyl-7-(p-methylphenyl)-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-one (1621314-74-6)

Guidance literature:

With urea hydrogen peroxide adduct; potassium carbonate; In water; acetone; at 70 ℃; for 2h; Temperature; Microwave irradiation;

DOI:10.1016/j.cclet.2014.03.048

Reference yield: 44.0%

2-amino-4-(4-methylphenyl)-4H-benzo[h]chromene-3-carbonitrile (144464-54-0) + chloroacetyl chloride (79-04-9) → 10-chloromethyl-7-(p-methylphenyl)-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-one (1621314-74-6)

Guidance literature:

In N,N-dimethyl-formamide; at 40 ℃; for 3h; Temperature; Microwave irradiation;

DOI:10.1016/j.cclet.2014.03.048

Reference yield:

2-amino-4-(4-methylphenyl)-4H-benzo[h]chromene-3-carbonitrile (144464-54-0) → 10-chloromethyl-7-(p-methylphenyl)-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-one (1621314-74-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0.33 h / 0 - 40 °C / Microwave irradiation

2: urea hydrogen peroxide adduct; potassium carbonate / acetone; water / 2 h / 70 °C / Microwave irradiation

With urea hydrogen peroxide adduct; potassium carbonate; In water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.cclet.2014.03.048

upstream raw materials:

2-chloro-N-(3-cyano-4-(p-methylphenyl)-4H-benzo[h]chromen-2-yl)acetamide

2-amino-4-(4-methylphenyl)-4H-benzo[h]chromene-3-carbonitrile

chloroacetyl chloride