2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methylbenzylthio)-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methylbenzylthio)-1,3,4-oxadiazole
• CAS No.: 1344999-25-2
• Molecular Formula: C₁₈H₁₆N₂O₃S
• Molecular Weight: 340.403
• Mol file: 1344999-25-2.mol

Synonyms:2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methylbenzylthio)-1,3,4-oxadiazole

Chemical Property of 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methylbenzylthio)-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methylbenzylthio)-1,3,4-oxadiazole

There total 4 articles about 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methylbenzylthio)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-bromomethyl-3-methyl-benzene (620-13-3) + 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2-thiol (928710-56-9) → 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methylbenzylthio)-1,3,4-oxadiazole (1344999-25-2)

Guidance literature:

With sodium hydroxide; In acetonitrile; Reflux;

DOI:10.1016/j.bmc.2011.08.013

Reference yield:

2,3-dihydro-1,4-benzodioxin-6-carboxylic acid (4442-54-0) → 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methylbenzylthio)-1,3,4-oxadiazole (1344999-25-2)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / ethanol / Reflux

3: potassium hydroxide / ethanol / 24 h / Reflux

4: sodium hydroxide / acetonitrile / Reflux

With sulfuric acid; hydrazine hydrate; potassium hydroxide; sodium hydroxide; In ethanol; acetonitrile;

DOI:10.1016/j.bmc.2011.08.013

Reference yield:

2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester (20197-75-5) → 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methylbenzylthio)-1,3,4-oxadiazole (1344999-25-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / Reflux

2: potassium hydroxide / ethanol / 24 h / Reflux

3: sodium hydroxide / acetonitrile / Reflux

With hydrazine hydrate; potassium hydroxide; sodium hydroxide; In ethanol; acetonitrile;

DOI:10.1016/j.bmc.2011.08.013

upstream raw materials:

1-bromomethyl-3-methyl-benzene

5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2-thiol

2,3-dihydro-1,4-benzodioxin-6-carboxylic acid

2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester