5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazole-2-thiol

Base Information

• Chemical Name: 5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazole-2-thiol
• CAS No.: 928710-56-9
• Molecular Formula: C₁₀H₈N₂O₃S
• Molecular Weight: 236.251
• Mol file: 928710-56-9.mol

Synonyms:5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2-thiol

Chemical Property of 5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazole-2-thiol

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazole-2-thiol

There total 7 articles about 5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazole-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

carbon disulfide (75-15-0,12122-00-8) + 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid hydrazide (98953-13-0) → 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2-thiol (928710-56-9)

Guidance literature:

With triethylamine; In ethanol; Reflux; Inert atmosphere;

DOI:10.1021/jm300309a

Reference yield:

2,3-dihydro-1,4-benzodioxin-6-carboxylic acid (4442-54-0) → 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2-thiol (928710-56-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / ethanol / Reflux

3: potassium hydroxide / ethanol / 24 h / Reflux

With sulfuric acid; hydrazine hydrate; potassium hydroxide; In ethanol;

DOI:10.1016/j.bmc.2011.08.013

Reference yield:

2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester (20197-75-5) → 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole-2-thiol (928710-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 48 h / Reflux

2: triethylamine / ethanol / Reflux; Inert atmosphere

With hydrazine hydrate; triethylamine; In ethanol;

DOI:10.1021/jm300309a

upstream raw materials:

carbon disulfide

2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid hydrazide

2,3-dihydro-1,4-benzodioxin-6-carboxylic acid

2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester

Downstream raw materials:

2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-fluorobenzylthio)-1,3,4-oxadiazole

2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-methylbenzylthio)-1,3,4-oxadiazole

2-(3-bromobenzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,3,4-oxadiazole

2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-iodobenzylthio)-1,3,4-oxadiazole