4-fluoro-α-oxobenzenepropanoic acid ethyl ester

Base Information

Chemical Name:4-fluoro-α-oxobenzenepropanoic acid ethyl ester
CAS No.:161038-68-2
Molecular Formula:C₁₁H₁₁FO₃
Molecular Weight:210.205
Hs Code.:

Synonyms:4-fluoro-α-oxobenzenepropanoic acid ethyl ester

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Chemical Property of 4-fluoro-α-oxobenzenepropanoic acid ethyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-fluoro-α-oxobenzenepropanoic acid ethyl ester

There total 3 articles about 4-fluoro-α-oxobenzenepropanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 223761-28-2
(4-fluorobenzyl)zinc(II) bromide

: 4755-77-5
Ethyl oxalyl chloride

: 161038-68-2
4-fluoro-α-oxobenzenepropanoic acid ethyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 0 ℃; for 12h; Inert atmosphere; Reflux;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 161038-68-2
4-fluoro-α-oxobenzenepropanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: chloro-trimethyl-silane; iodine / tetrahydrofuran / 10 h / Inert atmosphere; Reflux

2: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; chloro-trimethyl-silane; iodine; In tetrahydrofuran;

Reference yield:

: 95-92-1
oxalic acid diethyl ester

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 161038-68-2
4-fluoro-α-oxobenzenepropanoic acid ethyl ester

Guidance literature:: With iodine; magnesium; Yield given. Multistep reaction; 1.) ether, RT, 2 h, 2.) ether, RT, 30 min;
DOI:10.1002/jhet.5570310614