2-(ethoxycarbonyl)-3-(4-fluorophenyl)-α-methyl-1H-indole-1-acetic acid phenylmethyl ester

Base Information

Chemical Name:2-(ethoxycarbonyl)-3-(4-fluorophenyl)-α-methyl-1H-indole-1-acetic acid phenylmethyl ester
CAS No.:161038-69-3
Molecular Formula:C₂₇H₂₄FNO₄
Molecular Weight:445.49
Hs Code.:

Synonyms:2-(ethoxycarbonyl)-3-(4-fluorophenyl)-α-methyl-1H-indole-1-acetic acid phenylmethyl ester

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Chemical Property of 2-(ethoxycarbonyl)-3-(4-fluorophenyl)-α-methyl-1H-indole-1-acetic acid phenylmethyl ester

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Technology Process of 2-(ethoxycarbonyl)-3-(4-fluorophenyl)-α-methyl-1H-indole-1-acetic acid phenylmethyl ester

There total 3 articles about 2-(ethoxycarbonyl)-3-(4-fluorophenyl)-α-methyl-1H-indole-1-acetic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-63-0
phenylhydrazine

: 161038-69-3
2-(ethoxycarbonyl)-3-(4-fluorophenyl)-α-methyl-1H-indole-1-acetic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) conc. H₂SO₄, 2.) HCl(g) / 1.) 120 deg C, 15 min, 2.) ethanol, reflux, 1 h

2: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, RT, 18 h

With hydrogenchloride; sulfuric acid; sodium hydride;
DOI:10.1002/jhet.5570310614

Reference yield:

: 161038-68-2
4-fluoro-α-oxobenzenepropanoic acid ethyl ester

: 161038-69-3
2-(ethoxycarbonyl)-3-(4-fluorophenyl)-α-methyl-1H-indole-1-acetic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) conc. H₂SO₄, 2.) HCl(g) / 1.) 120 deg C, 15 min, 2.) ethanol, reflux, 1 h

2: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, RT, 18 h

With hydrogenchloride; sulfuric acid; sodium hydride;
DOI:10.1002/jhet.5570310614

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 161038-69-3
2-(ethoxycarbonyl)-3-(4-fluorophenyl)-α-methyl-1H-indole-1-acetic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Mg, I₂ / 1.) ether, RT, 2 h, 2.) ether, RT, 30 min

2: 1.) conc. H₂SO₄, 2.) HCl(g) / 1.) 120 deg C, 15 min, 2.) ethanol, reflux, 1 h

3: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, RT, 18 h

With hydrogenchloride; sulfuric acid; iodine; sodium hydride; magnesium;
DOI:10.1002/jhet.5570310614