Spiro[piperidine-4,4-[4H]pyrido[2,3-d][1,3]oxazin]-2(1H)-one (9CI)

Base Information

• Chemical Name: Spiro[piperidine-4,4-[4H]pyrido[2,3-d][1,3]oxazin]-2(1H)-one (9CI)
• CAS No.: 753440-87-8
• Molecular Formula: C11H13 N3 O2
• Molecular Weight: 217.22394
• Hs Code.: 2934999090
• Mol file: 753440-87-8.mol

Synonyms:Spiro[piperidine-4,4-[4H]pyrido[2,3-d][1,3]oxazin]-2(1H)-one (9CI)

Chemical Property of Spiro[piperidine-4,4-[4H]pyrido[2,3-d][1,3]oxazin]-2(1H)-one (9CI)

Chemical Property:

• Boiling Point: 352.4±42.0 °C(Predicted)
• PKA: 11.67±0.20(Predicted)
• Flash Point: 166.91oC
• PSA: 63.25000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 1.68920
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Spiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazin]-2'(1'H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Spiro[piperidine-4,4-[4H]pyrido[2,3-d][1,3]oxazin]-2(1H)-one (9CI)

There total 2 articles about Spiro[piperidine-4,4-[4H]pyrido[2,3-d][1,3]oxazin]-2(1H)-one (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7'-chloro-2'-oxo-1',2'-dihydro-1H-spiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-benzyl carboxylate (883984-95-0) → spiro[piperidine-4,4’-[4H]pyrido[2,3-d][1,3]oxazin]-2'(1‘H)-one (753440-87-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 24h; under 760.051 Torr;

Reference yield:

→ spiro[piperidine-4,4’-[4H]pyrido[2,3-d][1,3]oxazin]-2'(1‘H)-one (753440-87-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 24h; under 2250.23 Torr;

Reference yield:

spiro[piperidine-4,4’-[4H]pyrido[2,3-d][1,3]oxazin]-2'(1‘H)-one (753440-87-8) + 4-Nitrophenyl chloroformate (7693-46-1) → 4-nitrophenyl 2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxylate (1354640-51-9)

Guidance literature:

With triethylamine; In dichloromethane; benzene; at 20 ℃;

upstream raw materials:

7'-chloro-2'-oxo-1',2'-dihydro-1H-spiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-benzyl carboxylate

Downstream raw materials:

4-nitrophenyl 2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxylate

C₂₉H₃₂F₂N₆O₄

Refernces

• 1、 Burgey, Christopher S.,Potteiger, Craig M.,Deng, James Z.,Mosser, Scott D.,Salvatore, Christopher A.,Yu, Sean,Roller, Shane,Kane, Stefanie A.,Vacca, Joseph P.,Williams, Theresa M.. "Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines". scheme or table. p. 6368 - 6372. Retrieved 2010/05/02.
• 2、 -. "CGRP RECEPTOR ANTAGONISTS". Page/Page column 55. . Retrieved 2010/11/08.