H-Gly-Glu-Trp-Ala-Tyr-Asn-Pro-Ala-Thr-Gly-Lys-(N-Me)Phe-Ala-Val-Thr-Glu-NH₂

Base Information

• Chemical Name: H-Gly-Glu-Trp-Ala-Tyr-Asn-Pro-Ala-Thr-Gly-Lys-(N-Me)Phe-Ala-Val-Thr-Glu-NH₂
• CAS No.: 1620146-28-2
• Molecular Formula: C₈₁H₁₁₆N₂₀O₂₄
• Molecular Weight: 1753.93

Synonyms:H-Gly-Glu-Trp-Ala-Tyr-Asn-Pro-Ala-Thr-Gly-Lys-(N-Me)Phe-Ala-Val-Thr-Glu-NH₂

Chemical Property of H-Gly-Glu-Trp-Ala-Tyr-Asn-Pro-Ala-Thr-Gly-Lys-(N-Me)Phe-Ala-Val-Thr-Glu-NH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of H-Gly-Glu-Trp-Ala-Tyr-Asn-Pro-Ala-Thr-Gly-Lys-(N-Me)Phe-Ala-Val-Thr-Glu-NH₂

There total 2 articles about H-Gly-Glu-Trp-Ala-Tyr-Asn-Pro-Ala-Thr-Gly-Lys-(N-Me)Phe-Ala-Val-Thr-Glu-NH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

BOC-glycine (4530-20-5) + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-Val-OH (68858-20-8) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + Fmoc-Pro-OH (71989-31-6) + Fmoc-Glu(OtBu)-OH (71989-18-9) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + L-Asn(Trt) (132388-59-1) + (2S)-N-fluorenylmethyloxycarbonyl-2-amino-N-methyl-3-phenylpropanoic acid (77128-73-5,1362858-91-0) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) → H-Gly-Glu-Trp-Ala-Tyr-Asn-Pro-Ala-Thr-Gly-Lys-(N-Me)Phe-Ala-Val-Thr-Glu-NH2 (1620146-28-2)

Guidance literature:

Fmoc-Glu(OtBu)-OH; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 50 ℃; for 1h; Inert atmosphere;

With piperidine; In N,N-dimethyl-formamide; Inert atmosphere;

BOC-glycine; N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Val-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Pro-OH; Fmoc-Tyr(tBu)-OH; Fmoc-Lys(tert-butoxycarbonyl); Fmoc-Thr(tBu)-OH; L-Asn(Trt); (2S)-N-fluorenylmethyloxycarbonyl-2-amino-N-methyl-3-phenylpropanoic acid; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Further stages;

DOI:10.1016/j.bmc.2017.08.017

Reference yield:

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-Val-OH (68858-20-8) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + N-Fmoc-Tyr-OH (112883-29-1,92954-90-0) + Fmoc-Pro-OH (71989-31-6) + Fmoc-Glu(OtBu)-OH (71989-18-9) + Fmoc-Trp-OH (35737-15-6) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + Fmoc-Asn-OH (71989-16-7) + Fmoc-Lys-OH (105047-45-8) + (2S)-N-fluorenylmethyloxycarbonyl-2-amino-N-methyl-3-phenylpropanoic acid (77128-73-5,1362858-91-0) + Fmoc-L-E(γ-OtBu)-NH2 (104090-92-8) → H-Gly-Glu-Trp-Ala-Tyr-Asn-Pro-Ala-Thr-Gly-Lys-(N-Me)Phe-Ala-Val-Thr-Glu-NH2 (1620146-28-2)

Guidance literature:

Fmoc-L-E(γ-OtBu)-NH2; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 70 ℃; for 0.0666667h; Microwave irradiation;

With 4-methylpiperidin; In N,N-dimethyl-formamide; at 80 ℃; for 0.0333333h; Microwave irradiation;

N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Val-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; N-Fmoc-Tyr-OH; Fmoc-Pro-OH; Fmoc-Glu(OtBu)-OH; Fmoc-Trp-OH; Fmoc-Thr(tBu)-OH; Fmoc-Asn-OH; Fmoc-Lys-OH; (2S)-N-fluorenylmethyloxycarbonyl-2-amino-N-methyl-3-phenylpropanoic acid; Further stages;

DOI:10.1039/c4ob00886c

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-Val-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

N-Fmoc-Tyr-OH

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