(1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-ol

Base Information

Chemical Name:(1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-ol
CAS No.:908255-72-1
Molecular Formula:C₂₃H₃₆O₅
Molecular Weight:392.536
Hs Code.:

Synonyms:(1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-ol

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Chemical Property of (1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-ol

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Technology Process of (1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-ol

There total 8 articles about (1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {(1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-yloxy}-trimethyl-silane

: 908255-72-1
(1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jo0608725

Reference yield:

: 908255-69-6
(S)-2-((1R,7aR)-7a-Methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-propan-1-ol

: 908255-72-1
(1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / tetrabutylammonium iodide; NaH / tetrahydrofuran / 18 h / Heating

2: 0.308 g / m-chloroperoxybenzoic acid / CH₂Cl₂ / 2 h / -15 °C

3: 0.192 g / KOH / dimethylsulfoxide; H₂O / 18 h / 140 °C

4: triethylamine / tetrahydrofuran / 4 h / 20 °C

5: 4-(dimethylamino)pyridine; N,N-diisopropylethylamine / CH₂Cl₂ / 72 h / 20 °C

6: 1.17 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With dmap; potassium hydroxide; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jo0608725

Reference yield:

: 64190-55-2
Benzoic acid (S)-2-((1R,7aR)-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-propyl ester

: 908255-72-1
(1R,3aR,4R,7aR)-1-[(S)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-3a-methoxymethoxy-7a-methyl-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 0.062 g / NaOH / methanol; H₂O / 18 h / 20 °C

2: 74 percent / tetrabutylammonium iodide; NaH / tetrahydrofuran / 18 h / Heating

3: 0.308 g / m-chloroperoxybenzoic acid / CH₂Cl₂ / 2 h / -15 °C

4: 0.192 g / KOH / dimethylsulfoxide; H₂O / 18 h / 140 °C

5: triethylamine / tetrahydrofuran / 4 h / 20 °C

6: 4-(dimethylamino)pyridine; N,N-diisopropylethylamine / CH₂Cl₂ / 72 h / 20 °C

7: 1.17 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With dmap; potassium hydroxide; sodium hydroxide; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jo0608725