(S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol

Base Information

• Chemical Name: (S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol
• CAS No.: 941292-83-7
• Molecular Formula: C₂₅H₂₉NO
• Molecular Weight: 359.511
• Mol file: 941292-83-7.mol

Synonyms:(S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol

Chemical Property of (S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol

There total 5 articles about (S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

C25H27NO → (S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol (941292-83-7) + (R)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol

Guidance literature:

With sodium tetrahydroborate; In methanol; N,N-dimethyl-formamide; at -25 - 0 ℃;

DOI:10.1021/ja070063i

Reference yield: 62.0%

→ (S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol (941292-83-7) + (R)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol

Guidance literature:

Reference yield:

(S)-N-benzyl-N-(methoxymethyl)-1-phenylethan-1-amine (896721-70-3) → (S)-β-benzyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol (941292-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: L-proline / dimethylformamide / 24 h / -25 °C

2: 62 percent / NaBH₄ / methanol; dimethylformamide / -25 - 0 °C

With sodium tetrahydroborate; L-proline; In methanol; N,N-dimethyl-formamide; 1: Mannich reaction;

DOI:10.1021/ja070063i

upstream raw materials:

(S)-N-benzyl-N-(methoxymethyl)-1-phenylethan-1-amine

(S)-N-benzyl-1-phenylethylamine

3-phenyl-propionaldehyde

Downstream raw materials:

(S)-2-[(tert-butoxycarbonylamino)methyl]-3-phenylpropanoic acid