(6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt

Base Information

• Chemical Name: (6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt
• CAS No.: 1448015-73-3
• Molecular Formula: C₂HF₃O₂*C₂₁H₁₈N₄S
• Molecular Weight: 472.491
• Mol file: 1448015-73-3.mol

Synonyms:(6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt

Chemical Property of (6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt

There total 5 articles about (6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine (1012084-56-8) + [4-(4-bromophenyl)-1,3-thiazol-2-yl]-(6-methylpyridin-2-yl)amine (1310049-89-8) + trifluoroacetic acid (76-05-1) → (6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt (1448015-73-3)

Guidance literature:

2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine; [4-(4-bromophenyl)-1,3-thiazol-2-yl]-(6-methylpyridin-2-yl)amine; With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile; at 20 ℃;

DOI:10.1002/cmdc.201300007

Reference yield:

(6-methyl-pyridin-2-yl)-thiourea (49600-34-2) → (6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt (1448015-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 3 h / Reflux

2.1: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

2.2: 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; ethanol; 1.1: |Hantzsch Thiazole Synthesis;

DOI:10.1002/cmdc.201300007

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → (6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt (1448015-73-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetone / Reflux

2.1: sodium hydroxide / methanol / 0.5 h / Reflux

3.1: ethanol / 3 h / Reflux

4.1: tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

4.2: 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydroxide; tricyclohexylphosphine; In 1,4-dioxane; methanol; ethanol; acetone; 3.1: |Hantzsch Thiazole Synthesis;

DOI:10.1002/cmdc.201300007

upstream raw materials:

2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine

[4-(4-bromophenyl)-1,3-thiazol-2-yl]-(6-methylpyridin-2-yl)amine

trifluoroacetic acid

2-Amino-6-methylpyridine