N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-(morpholinomethyl)benzamide

Base Information

Chemical Name:N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-(morpholinomethyl)benzamide
CAS No.:404843-98-7
Molecular Formula:C₂₈H₂₈N₆O₂
Molecular Weight:480.569
Hs Code.:

Synonyms:N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-(morpholinomethyl)benzamide

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Chemical Property of N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-(morpholinomethyl)benzamide

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Technology Process of N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-(morpholinomethyl)benzamide

There total 14 articles about N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-(morpholinomethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.3%

: 110-91-8,99108-56-2
morpholine

: 404844-11-7
4-(chloromethyl)-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]-amino}phenyl)benzamide

: 404843-98-7
N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-(morpholinomethyl)benzamide

Guidance literature:: for 3h; Inert atmosphere; Schlenk technique; Reflux;
DOI:10.1021/op700270n

Reference yield:

: 1427026-52-5
C₁₉H₂₁BrN₂O₂

: 66521-66-2
4-pyridin-3-ylpyrimidin-2-ylamine

: 404843-98-7
N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-(morpholinomethyl)benzamide

Guidance literature:: With chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium t-butanolate; In 1,4-dioxane; water; tert-butyl alcohol; at 150 ℃; under 12929 Torr; Flow reactor;
DOI:10.1039/c2ob27002a

Reference yield:

: 350-03-8
methyl-3-pyridylketone

: 404843-98-7
N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-(morpholinomethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; 5,5-dimethyl-1,3-cyclohexadiene / 16 h / Reflux

2: sodium hydroxide / butan-1-ol / 24 h / Reflux

3: sodium t-butanolate; 1,8-diazabicyclo[5.4.0]undec-7-ene; chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II) / water; 1,4-dioxane; tert-butyl alcohol / 150 °C / 12929 Torr / Flow reactor

With chloro[2-(dicyclohexylphosphino)-3 ,6-dimethoxy-2’,4’, 6’-triisopropyl- 1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; sodium t-butanolate; In 1,4-dioxane; 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide; tert-butyl alcohol; butan-1-ol;
DOI:10.1039/c2ob27002a