N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}propioamide

Base Information

Chemical Name:N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}propioamide
CAS No.:1417529-61-3
Molecular Formula:C₁₆H₂₀N₄O₃
Molecular Weight:316.36
Hs Code.:

Synonyms:N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}propioamide

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Chemical Property of N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}propioamide

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Technology Process of N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}propioamide

There total 3 articles about N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}propioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417529-56-6
C₁₃H₁₆N₄O₂

: 79-03-8
propionyl chloride

: 1417529-61-3
N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}propioamide

Guidance literature:: C₁₃H₁₆N₄O₂; With tertiary amine; In dichloromethane; for 0.0833333h; Cooling;

propionyl chloride; In dichloromethane; at 0 - 20 ℃; for 1.16667h;
DOI:10.1016/j.tet.2012.11.037

Reference yield:

: 1417529-52-2
3-(2-ethoxyphenyl)-6-ethyl-4H-[1,2,4]triazin-5-one

: 1417529-61-3
N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}propioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 14 h / Reflux; Inert atmosphere

2.1: ammonia / tetrahydrofuran / 20 °C

3.1: tertiary amine / dichloromethane / 0.08 h / Cooling

3.2: 1.17 h / 0 - 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1016/j.tet.2012.11.037

Reference yield:

: 1417529-54-4
6-(1-bromoethyl)-3-(2-ethoxyphenyl)-4H-[1,2,4]triazin-5-one

: 1417529-61-3
N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}propioamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia / tetrahydrofuran / 20 °C

2.1: tertiary amine / dichloromethane / 0.08 h / Cooling

2.2: 1.17 h / 0 - 20 °C

With ammonia; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2012.11.037