ethyl 1-{5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoyl}-piperidine-4-carboxylate

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Chemical Name:ethyl 1-{5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoyl}-piperidine-4-carboxylate
CAS No.:1292849-85-4
Molecular Formula:C₃₁H₄₀Cl₂N₂O₅
Molecular Weight:591.575
Hs Code.:

Synonyms:ethyl 1-{5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoyl}-piperidine-4-carboxylate

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Chemical Property of ethyl 1-{5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoyl}-piperidine-4-carboxylate

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Technology Process of ethyl 1-{5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoyl}-piperidine-4-carboxylate

There total 6 articles about ethyl 1-{5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoyl}-piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1126-09-6
4-carbethoxypiperidine

: 1292849-84-3
5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid

: 1292849-85-4
ethyl 1-{5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoyl}-piperidine-4-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 1292849-83-2
ethyl 5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoate

: 1292849-85-4
ethyl 1-{5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoyl}-piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol; water / 12 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 74067-45-1
2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol

: 1292849-85-4
ethyl 1-{5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoyl}-piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; acetic acid

2: sodium hydrogencarbonate / dichloromethane / 2 h / 20 °C / Cooling with ice

3: potassium carbonate / methanol; water / 12 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.01.065