5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid

Base Information

Chemical Name:5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid
CAS No.:1292849-84-3
Molecular Formula:C₂₃H₂₇Cl₂NO₄
Molecular Weight:452.378
Hs Code.:

Synonyms:5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid

Suppliers and Price of 5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid

There total 5 articles about 5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1292849-83-2
ethyl 5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoate

: 1292849-84-3
5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid

Guidance literature:: ethyl 5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoate; With potassium carbonate; In methanol; water; at 20 ℃; for 12h;

With hydrogenchloride; In dichloromethane; water;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 74067-45-1
2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol

: 1292849-84-3
5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; acetic acid

2: sodium hydrogencarbonate / dichloromethane / 2 h / 20 °C / Cooling with ice

3: potassium carbonate / methanol; water / 12 h / 20 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; potassium carbonate; acetic acid; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 630-19-3
pivalaldehyde

: 1292849-84-3
5-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-5-oxopentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; acetic acid

2: sodium hydrogencarbonate / dichloromethane / 2 h / 20 °C / Cooling with ice

3: potassium carbonate / methanol; water / 12 h / 20 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; potassium carbonate; acetic acid; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.01.065