(2-{2-[4-(5-hydroxy-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

Base Information

Chemical Name:(2-{2-[4-(5-hydroxy-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester
CAS No.:374108-86-8
Molecular Formula:C₂₄H₂₉NO₆
Molecular Weight:427.497
Hs Code.:

(2-{2-[4-(5-hydroxy-pentyl)-3-oxo-3,4-dihydro-2<i>H</i>-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

Synonyms:(2-{2-[4-(5-hydroxy-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

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Chemical Property of (2-{2-[4-(5-hydroxy-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

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Technology Process of (2-{2-[4-(5-hydroxy-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

There total 9 articles about (2-{2-[4-(5-hydroxy-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374108-80-2
5-{2-[2-(2-methoxycarbonylmethyl-phenoxy)-ethyl]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl}-pentanoic acid

: 374108-86-8
(2-{2-[4-(5-hydroxy-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

Guidance literature:: With borane; In tetrahydrofuran; at -50 - 0 ℃; for 8h;
DOI:10.1021/jm0301888

Reference yield:

: 2067-33-6
5-bromopentanoic acid

: 374108-86-8
(2-{2-[4-(5-hydroxy-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; N,N-(dimethylamino)pyridine / CH₂Cl₂ / 7 h / 20 °C

2.1: sodium hydride / dimethylformamide / 0 °C

2.2: dimethylformamide / 0 - 20 °C

2.3: aq. CH₃SO₃H / methanol / 20 °C

3.1: tributylphosphine; 1,1'-(azodicarbonyl)dipiperidine / benzene / 20 °C

4.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2585.74 Torr

5.1: BH₃ / tetrahydrofuran / 8 h / -50 - 0 °C

With dmap; tributylphosphine; borane; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 3.1: Mitsunobu reaction;
DOI:10.1021/jm0301888

Reference yield:

: 60343-28-4
Benzyl 5-bromovalerate

: 374108-86-8
(2-{2-[4-(5-hydroxy-pentyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / dimethylformamide / 0 °C

1.2: dimethylformamide / 0 - 20 °C

1.3: aq. CH₃SO₃H / methanol / 20 °C

2.1: tributylphosphine; 1,1'-(azodicarbonyl)dipiperidine / benzene / 20 °C

3.1: H₂ / Pd/C / ethanol / 3 h / 20 °C / 2585.74 Torr

4.1: BH₃ / tetrahydrofuran / 8 h / -50 - 0 °C

With tributylphosphine; borane; hydrogen; sodium hydride; 1,1'-azodicarbonyl-dipiperidine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; benzene; 2.1: Mitsunobu reaction;
DOI:10.1021/jm0301888