methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-iodophenyl)acetamido)hexanoate

Base Information

Chemical Name:methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-iodophenyl)acetamido)hexanoate
CAS No.:1305196-76-2
Molecular Formula:C₂₀H₂₉IN₂O₅
Molecular Weight:504.365
Hs Code.:

Synonyms:methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-iodophenyl)acetamido)hexanoate

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Chemical Property of methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-iodophenyl)acetamido)hexanoate

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Technology Process of methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-iodophenyl)acetamido)hexanoate

There total 3 articles about methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-iodophenyl)acetamido)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1798-06-7
(4-iodophenyl)acetic acid

: 55757-60-3
N-α-(tert-butoxycarbonyl)-L-lysine methyl ester

: 1305196-76-2
methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-iodophenyl)acetamido)hexanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/chem.201002937

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 1305196-76-2
methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-iodophenyl)acetamido)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C / Inert atmosphere

2: palladium on carbon; hydrogen / methanol; dichloromethane / 0.5 h

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; palladium on carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1002/chem.201002937

Reference yield:

: 73548-77-3
Boc-L-Lys(Z)-OMe

: 1305196-76-2
methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-iodophenyl)acetamido)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / methanol; dichloromethane / 0.5 h

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; palladium on carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1002/chem.201002937