methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-(4-phenyl-2H-1,2,3-triazol-2-yl)phenyl)acetamido)hexanoate

Base Information

Chemical Name:methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-(4-phenyl-2H-1,2,3-triazol-2-yl)phenyl)acetamido)hexanoate
CAS No.:1305196-77-3
Molecular Formula:C₂₈H₃₅N₅O₅
Molecular Weight:521.616
Hs Code.:

Synonyms:methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-(4-phenyl-2H-1,2,3-triazol-2-yl)phenyl)acetamido)hexanoate

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Chemical Property of methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-(4-phenyl-2H-1,2,3-triazol-2-yl)phenyl)acetamido)hexanoate

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Technology Process of methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-(4-phenyl-2H-1,2,3-triazol-2-yl)phenyl)acetamido)hexanoate

There total 4 articles about methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-(4-phenyl-2H-1,2,3-triazol-2-yl)phenyl)acetamido)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55757-60-3
N-α-(tert-butoxycarbonyl)-L-lysine methyl ester

: 1305196-77-3
methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-(4-phenyl-2H-1,2,3-triazol-2-yl)phenyl)acetamido)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: potassium carbonate; L-proline; copper(l) chloride / dimethyl sulfoxide / 4 h / 85 °C / Inert atmosphere

With dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; L-proline; copper(l) chloride; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/chem.201002937

Reference yield:

: 1305196-76-2
methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-iodophenyl)acetamido)hexanoate

: 112614-96-7
4-phenyl-2H-[1,2,3]triazole

: 1305196-77-3
methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-(4-phenyl-2H-1,2,3-triazol-2-yl)phenyl)acetamido)hexanoate

Guidance literature:: With potassium carbonate; L-proline; copper(l) chloride; In dimethyl sulfoxide; at 85 ℃; for 4h; Inert atmosphere;
DOI:10.1002/chem.201002937

Reference yield:

: 73548-77-3
Boc-L-Lys(Z)-OMe

: 1305196-77-3
methyl 2-(tert-butoxycarbonylamino)-6-(2-(4-(4-phenyl-2H-1,2,3-triazol-2-yl)phenyl)acetamido)hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on carbon; hydrogen / methanol; dichloromethane / 0.5 h

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

3: potassium carbonate; L-proline; copper(l) chloride / dimethyl sulfoxide / 4 h / 85 °C / Inert atmosphere

With dmap; palladium on carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; L-proline; copper(l) chloride; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/chem.201002937