2,4-Dichloro-8-methylquinoline

Base Information

• Chemical Name: 2,4-Dichloro-8-methylquinoline
• CAS No.: 102878-20-6
• Molecular Formula: C₁₀H₇Cl₂N
• Molecular Weight: 212.078
• DSSTox Substance ID: DTXSID30372727
• Nikkaji Number: J3.392.654E
• Wikidata: Q82160584
• Mol file: 102878-20-6.mol

Synonyms:2,4-dichloro-8-methylquinoline;102878-20-6;SCHEMBL7699184;DTXSID30372727;MFCD01108969;AKOS004904234;SB69417;CS-0335623

Chemical Property of 2,4-Dichloro-8-methylquinoline

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 210.9955546
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

97% ^*data from raw suppliers

2,4-dichloro-8-methylquinoline 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C2C(=CC=C1)C(=CC(=N2)Cl)Cl

Technology Process of 2,4-Dichloro-8-methylquinoline

There total 4 articles about 2,4-Dichloro-8-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

malonic acid (141-82-2) + o-toluidine (95-53-4) → 2,4-dichloro-8-methylquinoline (102878-20-6)

Guidance literature:

With trichlorophosphate; for 4h; Reflux;

DOI:10.1021/ol301777s

Reference yield: 46.0%

4-hydroxy-8-methyl-1,2-dihydroquinolin-2-one (1677-42-5) → 2,4-dichloro-8-methylquinoline (102878-20-6)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 4h; Heating;

DOI:10.1080/10426500008082406

Reference yield:

8-methylquinoline-2,4-diol (1677-42-5) → 2,4-dichloro-8-methylquinoline (102878-20-6)

Guidance literature:

With trichlorophosphate;

DOI:10.1007/BF00905674

upstream raw materials:

8-methylquinoline-2,4-diol

4-hydroxy-8-methyl-1,2-dihydroquinolin-2-one

malonic acid

o-toluidine

Downstream raw materials:

4-chloro-8-methylquinoline-2(1H)-one

2,4,5-tris(dimethylamino)-8-methylquinolinium monopicrate

diethyl 4-(4-(2-chloro-8-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

dimethyl 4-(4-(2-chloro-8-methylquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylate