CHEMBRDG-BB 6631006

Base Information

• Chemical Name: CHEMBRDG-BB 6631006
• CAS No.: 1677-42-5
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Hs Code.: 2933790090
• Mol file: 1677-42-5.mol

Synonyms:4-hydroxy-8-methyl-1H-quinolin-2-one;

Chemical Property of CHEMBRDG-BB 6631006

Chemical Property:

• Vapor Pressure: 0.000118mmHg at 25°C
• Melting Point: >360 °C (decomp)(Solv: acetic acid (64-19-7))
• Boiling Point: 322.1oC at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 148.6oC
• PSA: 53.09000
• Density: 1.313g/cm3
• LogP: 1.54210
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-8-methylquinolin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMBRDG-BB 6631006

There total 8 articles about CHEMBRDG-BB 6631006 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-<(2-methylphenyl)amino>-3-oxopropanoic acid (78987-20-9) → 4-hydroxy-8-methyl-1,2-dihydroquinolin-2-one (1677-42-5)

Guidance literature:

With Methanesulfonic anhydride; In neat (no solvent); at 60 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tetlet.2020.151778

Reference yield: 87.0%

N1,N3-di-o-tolylmalonamide (10378-79-7) → 4-hydroxy-8-methyl-1,2-dihydroquinolin-2-one (1677-42-5)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; at 150 ℃; for 1.5h;

DOI:10.1016/j.cclet.2013.03.002

Reference yield: 84.3%

o-toluidine (95-53-4) + diethyl malonate (105-53-3) → 4-hydroxy-8-methyl-1,2-dihydroquinolin-2-one (1677-42-5)

Guidance literature:

With aluminum (III) chloride; Eaton′s reagent; at 90 ℃; for 6h; Inert atmosphere;

upstream raw materials:

N₁,N₃-di-o-tolylmalonamide

o-toluidine

diethyl malonate

3-<(2-methylphenyl)amino>-3-oxopropanoic acid

Downstream raw materials:

8-methyl-4-tosyloxyquinolin-2(1H)-one

2,4-dichloro-8-methylquinoline

C₁₆H₁₂N₄O₄

C₁₈H₁₅N₃O₃