2-[4-(4'-acetylbiphenylyl)]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-[4-(4'-acetylbiphenylyl)]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole
• CAS No.: 124454-24-6
• Molecular Formula: C₂₆H₂₄N₂O₂
• Molecular Weight: 396.489
• Mol file: 124454-24-6.mol

Synonyms:2-[4-(4'-acetylbiphenylyl)]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole

Chemical Property of 2-[4-(4'-acetylbiphenylyl)]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(4'-acetylbiphenylyl)]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole

There total 1 articles about 2-[4-(4'-acetylbiphenylyl)]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(4-tert-butylphenyl)-5-(4-biphenylyl)-1,3,4-oxadiazole (15082-28-7) + acetyl chloride (75-36-5) → 2-[4-(4'-acetylbiphenylyl)]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (124454-24-6)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; for 5h; Reflux;

DOI:10.1002/pola.23796

Reference yield: 97.0%

2-[4-(4'-acetylbiphenylyl)]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (124454-24-6) → 2-[4-(4'-(1-hydroxyethyl)biphenylyl)]-5-(4-tert-butyl-phenyl)-1,3,4-oxadiazole

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 5h;

DOI:10.1002/pola.23796

Reference yield:

2-[4-(4'-acetylbiphenylyl)]-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (124454-24-6) → 2-(4-(tert-butyl)phenyl)-5-(4'-vinyl-[1,1'-biphenyl]-4-yl)-2,5-dihydro-1,3,4-oxadiazole (85884-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.99 g / NaBH₄ / ethanol / 5 h / 20 °C

2: 1.70 g / p-TsOH*H₂O / toluene / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In ethanol; toluene;

DOI:10.1021/ma0115850

upstream raw materials:

2-(4-tert-butylphenyl)-5-(4-biphenylyl)-1,3,4-oxadiazole

acetyl chloride

Downstream raw materials:

2-(4-(tert-butyl)phenyl)-5-(4'-vinyl-[1,1'-biphenyl]-4-yl)-2,5-dihydro-1,3,4-oxadiazole