SKF 108728

Base Information

• Chemical Name: SKF 108728
• CAS No.: 133486-00-7
• Molecular Formula: C₂₃H₂₆N₂O₃S
• Molecular Weight: 410.537
• Mol file: 133486-00-7.mol

Synonyms:SKF 108728

Chemical Property of SKF 108728

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of SKF 108728

There total 11 articles about SKF 108728 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-[2-n-Butyl-1{(4-methoxy-3-methylphenyl)methyl}-1H-imidazol-5yl]-2-(2-thienyl)methyl-2-propenoic Acid → SKF 108728 (133486-00-7)

Guidance literature:

With boron tribromide; In dichloromethane;

Reference yield:

methyl 3-(2-thienyl)propanoate (16862-05-8) → SKF 108728 (133486-00-7)

Guidance literature:

Multi-step reaction with 5 steps

1: lithium diisopropyl amide / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

2: dmap / dichloromethane / 19 h

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 1 h / 100 °C

4: sodium hydroxide / ethanol / 17 h / Ambient temperature

5: boron tribromide

With dmap; sodium hydroxide; boron tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In ethanol; dichloromethane; toluene;

DOI:10.1021/jm00065a011

Reference yield:

2-n-butyl-4-(hydroxymethyl)imidazole (68283-19-2) → SKF 108728 (133486-00-7)

Guidance literature:

Multi-step reaction with 8 steps

1: manganese(IV) oxide / dichloromethane / 24 h / Ambient temperature

2: potassium carbonate / N,N-dimethyl-formamide / 22 h / 25 °C

3: ammonium hydroxide / 1.) 100 deg C, 2.5 h, 2.) EtOAc

4: lithium diisopropyl amide / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

5: dmap / dichloromethane / 19 h

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 1 h / 100 °C

7: sodium hydroxide / ethanol / 17 h / Ambient temperature

8: boron tribromide

With dmap; manganese(IV) oxide; ammonium hydroxide; sodium hydroxide; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00065a011

upstream raw materials:

(E)-3-[2-n-butyl-1-{(4-methoxy-3-methylphenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

methyl 3-(2-thienyl)propanoate

2-n-butyl-4-(hydroxymethyl)imidazole

2-n-butyl-1H-imidazole-4-carbaldehyde

Refernces

• 1、 -. "Substituted 5-((tetrazolyl)alkenyl)imidazoles and pharmaceutical methods of use thereof". . . Retrieved 2008/06/13.