2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid

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Chemical Name:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid
CAS No.:1403380-99-3
Molecular Formula:C₂₂H₂₆O₅
Molecular Weight:370.445
Hs Code.:

Synonyms:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid

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Chemical Property of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid

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Technology Process of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid

There total 8 articles about 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1403382-04-6
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxycarbonyl)phenyl]acetic acid

: 1403380-99-3
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid

Guidance literature:: 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxycarbonyl)phenyl]acetic acid; With lithium borohydride; cyclohexylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 53663-39-1
3-methyl-2-bromobenzoic acid

: 1403380-99-3
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 20 h / Reflux

2.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Inert atmosphere; Reflux

2.2: 0.25 h / 60 °C / irradiated 200W

3.1: zinc(II) iodide / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / 240 h / 20 °C

5.1: perchloric acid / 2 h / -10 - 0 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 80 °C / irradiated 200W

7.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C

8.1: cyclohexylamine; lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; lithium borohydride; perchloric acid; sulfuric acid; water; sodium carbonate; cyclohexylamine; zinc(II) iodide; lithium hydroxide; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water;

Reference yield:

: 131001-86-0
methyl 2-bromo-3-methylbenzoate

: 1403380-99-3
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Inert atmosphere; Reflux

1.2: 0.25 h / 60 °C / irradiated 200W

2.1: zinc(II) iodide / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / 240 h / 20 °C

4.1: perchloric acid / 2 h / -10 - 0 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 80 °C / irradiated 200W

6.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C

7.1: cyclohexylamine; lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; lithium borohydride; perchloric acid; water; sodium carbonate; cyclohexylamine; zinc(II) iodide; lithium hydroxide; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water;