2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxymethyl)phenyl]acetic acid

Base Information

Chemical Name:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxymethyl)phenyl]acetic acid
CAS No.:1403381-00-9
Molecular Formula:C₂₃H₂₈O₅
Molecular Weight:384.472
Hs Code.:

Synonyms:2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxymethyl)phenyl]acetic acid

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Chemical Property of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxymethyl)phenyl]acetic acid

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Technology Process of 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxymethyl)phenyl]acetic acid

There total 9 articles about 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxymethyl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1403380-99-3
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid

: 74-88-4
methyl iodide

: 1403381-00-9
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxymethyl)phenyl]acetic acid

Guidance literature:: 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(hydroxymethyl)phenyl]acetic acid; methyl iodide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 24h; Inert atmosphere;

With disodium hydrogenphosphate; ammonium chloride; In tetrahydrofuran; water; mineral oil; pH=3;

Reference yield:

: 131001-86-0
methyl 2-bromo-3-methylbenzoate

: 1403381-00-9
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxymethyl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Inert atmosphere; Reflux

1.2: 0.25 h / 60 °C / irradiated 200W

2.1: zinc(II) iodide / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / 240 h / 20 °C

4.1: perchloric acid / 2 h / -10 - 0 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 80 °C / irradiated 200W

6.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C

7.1: cyclohexylamine; lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

8.1: sodium hydride / tetrahydrofuran; mineral oil / 24 h / 0 - 20 °C / Inert atmosphere

8.2: pH 3

With hydrogenchloride; N-Bromosuccinimide; lithium borohydride; perchloric acid; water; sodium hydride; sodium carbonate; cyclohexylamine; zinc(II) iodide; lithium hydroxide; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water; mineral oil;

Reference yield:

: 53663-39-1
3-methyl-2-bromobenzoic acid

: 1403381-00-9
2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)-3-(methoxymethyl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / 20 h / Reflux

2.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / Inert atmosphere; Reflux

2.2: 0.25 h / 60 °C / irradiated 200W

3.1: zinc(II) iodide / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / 240 h / 20 °C

5.1: perchloric acid / 2 h / -10 - 0 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 80 °C / irradiated 200W

7.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C

8.1: cyclohexylamine; lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

9.1: sodium hydride / tetrahydrofuran; mineral oil / 24 h / 0 - 20 °C / Inert atmosphere

9.2: pH 3

With hydrogenchloride; N-Bromosuccinimide; lithium borohydride; perchloric acid; sulfuric acid; water; sodium hydride; sodium carbonate; cyclohexylamine; zinc(II) iodide; lithium hydroxide; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water; mineral oil;