(7S,9R,10R)-1-Benzenesulfonyl-9,10-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one

Base Information

Chemical Name:(7S,9R,10R)-1-Benzenesulfonyl-9,10-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one
CAS No.:380579-77-1
Molecular Formula:C₃₉H₆₆O₇SSi₂
Molecular Weight:735.186
Hs Code.:

Synonyms:(7S,9R,10R)-1-Benzenesulfonyl-9,10-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one

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Chemical Property of (7S,9R,10R)-1-Benzenesulfonyl-9,10-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one

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Technology Process of (7S,9R,10R)-1-Benzenesulfonyl-9,10-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one

There total 8 articles about (7S,9R,10R)-1-Benzenesulfonyl-9,10-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1053654-32-2
(E)-(7S,9R,10R)-1-Benzenesulfonyl-9,10-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-undec-4-en-3-one

: 380579-77-1
(7S,9R,10R)-1-Benzenesulfonyl-9,10-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one

Guidance literature:: With hydrogen; palladium dihydroxide; In ethyl acetate; at 20 ℃; for 12h;
DOI:10.1021/ol016800b

Reference yield:

: 51916-36-0
2-Phenylthiomethyl-2-methyl-1-propanol

: 380579-77-1
(7S,9R,10R)-1-Benzenesulfonyl-9,10-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / oxone / tetrahydrofuran; methanol; H₂O / 2 h / 20 °C

2: RuCl₃; NaIO₄ / acetonitrile; CCl₄; H₂O / 2 h / 0 - 20 °C

3: K₂CO₃ / dimethylformamide / 12 h / 20 °C

4: 65 percent / n-BuLi / tetrahydrofuran; hexane / 4 h / -78 - 20 °C

5: LiCl; i-Pr₂NEt / acetonitrile / 16 h / 20 °C

6: 80 percent / H₂ / Pd(OH)2/C / ethyl acetate / 12 h / 20 °C

With ruthenium trichloride; Oxone; sodium periodate; n-butyllithium; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium dihydroxide; In tetrahydrofuran; methanol; tetrachloromethane; hexane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 5: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/ol016800b

Reference yield:

: 38435-02-8
2,2-dimethyl-3-(phenylsulfonyl)propanoic acid

: 380579-77-1
(7S,9R,10R)-1-Benzenesulfonyl-9,10-bis-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-2,2-dimethyl-undecan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 12 h / 20 °C

2: 65 percent / n-BuLi / tetrahydrofuran; hexane / 4 h / -78 - 20 °C

3: LiCl; i-Pr₂NEt / acetonitrile / 16 h / 20 °C

4: 80 percent / H₂ / Pd(OH)2/C / ethyl acetate / 12 h / 20 °C

With n-butyllithium; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; palladium dihydroxide; In tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 3: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/ol016800b