N⁴-(3-chloro-4-fluorophenyl)-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-4,6-quinazolinediamine

Base Information

• Chemical Name: N⁴-(3-chloro-4-fluorophenyl)-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-4,6-quinazolinediamine
• CAS No.: 451494-30-7
• Molecular Formula: C₂₄H₂₆ClFN₆
• Molecular Weight: 452.962

Synonyms:N⁴-(3-chloro-4-fluorophenyl)-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-4,6-quinazolinediamine

Chemical Property of N⁴-(3-chloro-4-fluorophenyl)-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-4,6-quinazolinediamine

Chemical Property:

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Technology Process of N⁴-(3-chloro-4-fluorophenyl)-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-4,6-quinazolinediamine

There total 1 articles about N⁴-(3-chloro-4-fluorophenyl)-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-4,6-quinazolinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(3-chloro-4-fluorophenyl)-{7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-6-nitro-4-quinazolinyl}amine (451494-31-8) → N4-(3-chloro-4-fluorophenyl)-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-4,6-quinazolinediamine (451494-30-7)

Guidance literature:

With hydrazine; iron(III) chloride; In methanol; for 4h; Heating / reflux;

Reference yield: 70.0%

N4-(3-chloro-4-fluorophenyl)-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-4,6-quinazolinediamine (451494-30-7) → C24H28ClFN6 (451494-81-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 12h;

Reference yield: 64.0%

N4-(3-chloro-4-fluorophenyl)-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-4,6-quinazolinediamine (451494-30-7) + acrylic acid (79-10-7) + acryloyl chloride (814-68-6,25189-84-8) → MP-412 (451492-95-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Product distribution / selectivity;

upstream raw materials:

(3-chloro-4-fluorophenyl)-{7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-6-nitro-4-quinazolinyl}amine

Downstream raw materials:

MP-412

C₂₆H₂₈ClFN₆O₂S

C₂₈H₂₈ClFN₆O

C₂₄H₂₈ClFN₆

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