(+/-)-5-(benzyloxy)-3-hydroxy-N-methoxy-N-methylpentanamide

Base Information

Chemical Name:(+/-)-5-(benzyloxy)-3-hydroxy-N-methoxy-N-methylpentanamide
CAS No.:1256553-68-0
Molecular Formula:C₁₄H₂₁NO₄
Molecular Weight:267.325
Hs Code.:

Synonyms:(+/-)-5-(benzyloxy)-3-hydroxy-N-methoxy-N-methylpentanamide

Suppliers and Price of (+/-)-5-(benzyloxy)-3-hydroxy-N-methoxy-N-methylpentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-5-(benzyloxy)-3-hydroxy-N-methoxy-N-methylpentanamide

Chemical Property:

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Technology Process of (+/-)-5-(benzyloxy)-3-hydroxy-N-methoxy-N-methylpentanamide

There total 3 articles about (+/-)-5-(benzyloxy)-3-hydroxy-N-methoxy-N-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 166890-33-1
methyl (+/-)-5-(benzyloxy)-3-hydroxypentanoate

: 1256553-68-0
(+/-)-5-(benzyloxy)-3-hydroxy-N-methoxy-N-methylpentanamide

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at -5 - 20 ℃; Inert atmosphere;
DOI:10.1055/s-0030-1257890

Reference yield: 74.0%

: 158414-68-7
ethyl 5-(benzyloxy)-3-hydroxypentanoate

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1256553-68-0
(+/-)-5-(benzyloxy)-3-hydroxy-N-methoxy-N-methylpentanamide

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at -10 - 0 ℃; for 3h; Inert atmosphere;

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 1256553-68-0
(+/-)-5-(benzyloxy)-3-hydroxy-N-methoxy-N-methylpentanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / -10 - 0 °C / Inert atmosphere

1.2: 0.17 h / -10 - 0 °C

1.3: 0.5 h

2.1: methanol; sodium tetrahydroborate / 2.5 h / 0 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -10 - 0 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; isopropylmagnesium chloride; sodium hydride; In tetrahydrofuran; mineral oil;