(R)-(4-fluorophenyl)[8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone

Base Information

Chemical Name:(R)-(4-fluorophenyl)[8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone
CAS No.:1338373-30-0
Molecular Formula:C₂₂H₁₈FN₅O
Molecular Weight:387.416
Hs Code.:

Synonyms:(R)-(4-fluorophenyl)[8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(4-fluorophenyl)[8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone

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Technology Process of (R)-(4-fluorophenyl)[8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone

There total 5 articles about (R)-(4-fluorophenyl)[8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₅N₅

: 403-43-0
4-fluorobenzoyl chloride

: 1338373-30-0
(R)-(4-fluorophenyl)[8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone

Guidance literature:: With triethylamine; In dichloromethane; for 0.25h;
DOI:10.1016/j.bmc.2019.03.059

Reference yield:

: 1338372-76-1
(4-fluorophenyl)(8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

: 1338373-74-2
(S)-(4-fluorophenyl)(8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone

: 1338373-30-0
(R)-(4-fluorophenyl)[8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone

Guidance literature:: With diethylamine; Resolution of racemate;

Reference yield:

: 1429560-52-0
(R)-1-(2,4-dimethoxybenzyl)-5-ethoxy-6-methyl-1,2,3,6-tetrahydropyrazine

: 1338373-30-0
(R)-(4-fluorophenyl)[8-methyl-3-(quinolin-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]methanone

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 17 h / 70 °C

2: trifluoroacetic acid / dichloromethane / 4.5 h / 0 - 20 °C

3: triethylamine / dichloromethane / 0.25 h

With triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2019.03.059