[1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-diyl]dimethanol

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Chemical Name:[1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-diyl]dimethanol
CAS No.:1383256-27-6
Molecular Formula:C₁₈H₁₃ClFNO₂S
Molecular Weight:361.824
Hs Code.:

Synonyms:[1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-diyl]dimethanol

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Chemical Property of [1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-diyl]dimethanol

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Technology Process of [1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-diyl]dimethanol

There total 2 articles about [1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-diyl]dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1383256-17-4
dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate

: 1383256-27-6
[1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-diyl]dimethanol

Guidance literature:: dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate; With lithium aluminium tetrahydride; In diethyl ether; dichloromethane; at -5 - 0 ℃; for 0.333333h;

With water; In diethyl ether; dichloromethane; at -5 - 0 ℃;
DOI:10.1016/j.ejmech.2012.03.030

Reference yield:

: 1383256-08-3
3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile

: 1383256-27-6
[1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-diyl]dimethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrafluoroboric acid / dichloromethane / 3 h / 20 °C

1.2: 13 h / 35 °C

2.1: lithium aluminium tetrahydride / diethyl ether; dichloromethane / 0.33 h / -5 - 0 °C

2.2: -5 - 0 °C

With lithium aluminium tetrahydride; tetrafluoroboric acid; In diethyl ether; dichloromethane;
DOI:10.1016/j.ejmech.2012.03.030