3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile

Base Information

Chemical Name:3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile
CAS No.:1383256-08-3
Molecular Formula:C₁₅H₈ClFN₂OS
Molecular Weight:318.759
Hs Code.:

Synonyms:3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile

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Chemical Property of 3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile

Chemical Property:

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Technology Process of 3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile

There total 1 articles about 3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 95-16-9
1,3-Benzothiazole

: 7677-24-9
trimethylsilyl cyanide

: 65055-17-6
3-chloro-4-fluorobenzoyl chloride

: 1383256-08-3
3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile

Guidance literature:: With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 17h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.03.030

Reference yield: 17.0%

: 1383256-08-3
3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile

: 762-42-5
dimethyl acetylenedicarboxylate

: 1383256-17-4
dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate

Guidance literature:: 3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile; With tetrafluoroboric acid; In dichloromethane; at 20 ℃; for 3h;

dimethyl acetylenedicarboxylate; In N,N-dimethyl-formamide; at 35 ℃; for 13h;
DOI:10.1016/j.ejmech.2012.03.030

Reference yield:

: 1383256-08-3
3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile

: 1383256-27-6
[1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-diyl]dimethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrafluoroboric acid / dichloromethane / 3 h / 20 °C

1.2: 13 h / 35 °C

2.1: lithium aluminium tetrahydride / diethyl ether; dichloromethane / 0.33 h / -5 - 0 °C

2.2: -5 - 0 °C

With lithium aluminium tetrahydride; tetrafluoroboric acid; In diethyl ether; dichloromethane;
DOI:10.1016/j.ejmech.2012.03.030