dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate

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Chemical Name:dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate
CAS No.:1383256-17-4
Molecular Formula:C₂₀H₁₃ClFNO₄S
Molecular Weight:417.845
Hs Code.:

Synonyms:dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate

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Chemical Property of dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate

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Technology Process of dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate

There total 2 articles about dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1383256-08-3
3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile

: 762-42-5
dimethyl acetylenedicarboxylate

: 1383256-17-4
dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate

Guidance literature:: 3-(3-chloro-4-fluorobenzoyl)-2,3-dihydrobenzo[d]thiazole-2-carbonitrile; With tetrafluoroboric acid; In dichloromethane; at 20 ℃; for 3h;

dimethyl acetylenedicarboxylate; In N,N-dimethyl-formamide; at 35 ℃; for 13h;
DOI:10.1016/j.ejmech.2012.03.030

Reference yield:

: 95-16-9
1,3-Benzothiazole

: 1383256-17-4
dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / dichloromethane / 17 h / 20 °C / Inert atmosphere

2.1: tetrafluoroboric acid / dichloromethane / 3 h / 20 °C

2.2: 13 h / 35 °C

With aluminum (III) chloride; tetrafluoroboric acid; In dichloromethane;
DOI:10.1016/j.ejmech.2012.03.030

Reference yield: 75.0%

: 1383256-17-4
dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate

: 1383256-27-6
[1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-diyl]dimethanol

Guidance literature:: dimethyl 1-(3-chloro-4-fluorophenyl)benzo[d]pyrrolo[2,1-b]thiazole-2,3-dicarboxylate; With lithium aluminium tetrahydride; In diethyl ether; dichloromethane; at -5 - 0 ℃; for 0.333333h;

With water; In diethyl ether; dichloromethane; at -5 - 0 ℃;
DOI:10.1016/j.ejmech.2012.03.030