[(1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-(2-iodo-3,5-dimethoxy-phenoxy)-propoxy]-tert-butyl-dimethyl-silane

Base Information

• Chemical Name: [(1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-(2-iodo-3,5-dimethoxy-phenoxy)-propoxy]-tert-butyl-dimethyl-silane
• CAS No.: 187404-34-8
• Molecular Formula: C₃₂H₄₃IO₆Si
• Molecular Weight: 678.68

Synonyms:[(1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-(2-iodo-3,5-dimethoxy-phenoxy)-propoxy]-tert-butyl-dimethyl-silane

Chemical Property of [(1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-(2-iodo-3,5-dimethoxy-phenoxy)-propoxy]-tert-butyl-dimethyl-silane

Chemical Property:

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Technology Process of [(1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-(2-iodo-3,5-dimethoxy-phenoxy)-propoxy]-tert-butyl-dimethyl-silane

There total 3 articles about [(1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-(2-iodo-3,5-dimethoxy-phenoxy)-propoxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-iodo-3,5-dimethyoxyphenol (187404-37-1) + (2R,3R)-1,4-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butan-2-ol (187404-33-7) → [(1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-(2-iodo-3,5-dimethoxy-phenoxy)-propoxy]-tert-butyl-dimethyl-silane (187404-34-8)

Guidance literature:

With tributylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1016/S0040-4039(96)02475-6

Reference yield:

(R,R)-1,4-dibenzylthreitol (91604-41-0) → [(1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-(2-iodo-3,5-dimethoxy-phenoxy)-propoxy]-tert-butyl-dimethyl-silane (187404-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 68 percent / DEAD, n-Bu₃P / tetrahydrofuran / 24 h / Ambient temperature

With 1H-imidazole; tributylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(96)02475-6

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → [(1R,2S)-3-Benzyloxy-1-benzyloxymethyl-2-(2-iodo-3,5-dimethoxy-phenoxy)-propoxy]-tert-butyl-dimethyl-silane (187404-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 68 percent / DEAD, n-Bu₃P / tetrahydrofuran / 24 h / Ambient temperature

With 1H-imidazole; tributylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(96)02475-6

upstream raw materials:

2-iodo-3,5-dimethyoxyphenol

(2R,3R)-1,4-Bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-butan-2-ol

(R,R)-1,4-dibenzylthreitol

tert-butyldimethylsilyl chloride

Downstream raw materials:

(2R,3S)-1,4-Bis-benzyloxy-3-(2-iodo-3,5-dimethoxy-phenoxy)-butan-2-ol

C₃₄H₃₆I₂O₈

4′,4′′′,7,7′′-tetra-O-methylcupressuflavone

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