(2R)-2-benzoyloxy-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane

Base Information

• Chemical Name: (2R)-2-benzoyloxy-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane
• CAS No.: 158358-98-6
• Molecular Formula: C₂₀H₃₂F₂O₃Si
• Molecular Weight: 386.555
• Mol file: 158358-98-6.mol

Synonyms:(2R)-2-benzoyloxy-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane

Chemical Property of (2R)-2-benzoyloxy-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-benzoyloxy-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane

There total 6 articles about (2R)-2-benzoyloxy-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

benzoyl chloride (98-88-4) + (2R)-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane (158358-97-5) → (2R)-2-benzoyloxy-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane (158358-98-6)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/0957-4166(94)80051-0

Reference yield:

(2R)-1,2-O-isopropylidene-3-hydroxyheptan-1,2-diol (1093352-94-3) → (2R)-2-benzoyloxy-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane (158358-98-6)

Guidance literature:

Multi-step reaction with 5 steps

1: (COCl)2, DMSO

2: diethylaminosulfur trifluoride / CH₂Cl₂

3: 78 percent / 4 N HCl / tetrahydrofuran / 12 h / 20 °C

4: 82 percent / DMAP / CH₂Cl₂ / 16 h / 20 °C

5: 84 percent / pyridine / CH₂Cl₂ / 16 h / 20 °C

With pyridine; hydrogenchloride; dmap; oxalyl dichloride; diethylamino-sulfur trifluoride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0957-4166(94)80051-0

Reference yield:

(2R)-1,2-O-isopropylidene-3-oxoheptan-1,2-diol (106513-40-0) → (2R)-2-benzoyloxy-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane (158358-98-6)

Guidance literature:

Multi-step reaction with 4 steps

1: diethylaminosulfur trifluoride / CH₂Cl₂

2: 78 percent / 4 N HCl / tetrahydrofuran / 12 h / 20 °C

3: 82 percent / DMAP / CH₂Cl₂ / 16 h / 20 °C

4: 84 percent / pyridine / CH₂Cl₂ / 16 h / 20 °C

With pyridine; hydrogenchloride; dmap; diethylamino-sulfur trifluoride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0957-4166(94)80051-0

upstream raw materials:

benzoyl chloride

(2R)-1-tert-butyldimethylsilyloxy-3,3-difluoro2-hydroxyheptane

(2R)-1,2-O-isopropylidene-3-hydroxyheptan-1,2-diol

(2R)-1,2-O-isopropylidene-3-oxoheptan-1,2-diol

Downstream raw materials:

(2R)-benzoyloxy-3,3-difluoroheptanal

(4R)-4-benzoyloxy-5,5-difluoro-2E-nonenal

(2R)-2-benzoyloxy-1-hydroxy-3,3-difluoroheptane