2-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Base Information

Chemical Name:2-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one
CAS No.:1044870-95-2
Molecular Formula:C₂₃H₂₈N₄O₃
Molecular Weight:408.5
Hs Code.:

Synonyms:2-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Suppliers and Price of 2-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

There total 11 articles about 2-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1044872-39-0
4-(4-ethyl piperazin-1-ylmethyl)benzaldehyde

: 63920-73-0
2-amino-4,6-dimethoxybenzamide

: 1044870-95-2
2-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Guidance literature:: With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 150 ℃; for 5h;

Reference yield:

: 21577-57-1
2-amino-4,6-dimethoxybenzoic acid

: 1044870-95-2
2-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / tetrahydrofuran / 3 h / 20 °C

1.2: 16 h / 20 °C

2.1: toluene-4-sulfonic acid; sodium hydrogensulfite / N,N-dimethyl acetamide / 5 h / 150 °C

With 4-methyl-morpholine; benzotriazol-1-ol; toluene-4-sulfonic acid; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 622381-68-4
(4-(4-ethyl piperazin-1-ylmethyl)phenyl)-methanol

: 1044870-95-2
2-(4-((4-ethylpiperazin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; dimethyl sulfoxide / dimethyl sulfoxide / 1 h / -78 °C

2: sodium hydrogensulfite; toluene-4-sulfonic acid / water; N,N-dimethyl acetamide / 5 h / 150 °C

With oxalyl dichloride; toluene-4-sulfonic acid; sodium hydrogensulfite; dimethyl sulfoxide; In N,N-dimethyl acetamide; water; dimethyl sulfoxide;