3-hydroxymethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole

Base Information

• Chemical Name: 3-hydroxymethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole
• CAS No.: 443920-00-1
• Molecular Formula: C₁₇H₁₆N₂O₃S
• Molecular Weight: 328.392
• Mol file: 443920-00-1.mol

Synonyms:3-hydroxymethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole

Chemical Property of 3-hydroxymethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3-hydroxymethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole

There total 10 articles about 3-hydroxymethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester (443919-99-1) → 3-hydroxymethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole (443920-00-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jm2001376

Reference yield:

C21H22N4O5S (1242450-20-9) → 5,6-dhydrouracil (504-07-4) + 3-hydroxymethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole (443920-00-1)

Guidance literature:

In water; at 37 ℃; for 3h; pH=7.4; aq. phosphate buffer;

DOI:10.1021/ol101049g

Reference yield:

C20H20N4O5S (1242450-18-5) → 2,4-imidazolidinedione (461-72-3) + 3-hydroxymethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole (443920-00-1)

Guidance literature:

In water; at 37 ℃; pH=7.4; aq. phosphate buffer;

DOI:10.1021/ol101049g

upstream raw materials:

1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

ethyl-(Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoate

acetophenone

ethyl 2,4-dioxo-4-phenylbutyrate

Downstream raw materials:

1-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-3-(3-trifluoromethyl-phenyl)-urea

C₁₉H₂₁N₃O₂S

2-{3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propyl}-isoindole-1,3-dione

3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]-propan-1-ol