p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside

Base Information

Chemical Name:p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside
CAS No.:1071226-23-7
Molecular Formula:C₄₇H₅₀Cl₃NO₁₈S
Molecular Weight:1055.33
Hs Code.:

p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside

Synonyms:p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside

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Chemical Property of p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside

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Technology Process of p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside

There total 8 articles about p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1071226-16-8
p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-4,6-O-benzylidene-1-thio-β-D-galactopyranoside

: 98-88-4
benzoyl chloride

: 1071226-23-7
p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1002/chem.200800757

Reference yield:

: C₂₇H₃₂Cl₃NO₁₂S

: 1071226-23-7
p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; water / acetone; water / 0 - 20 °C / Inert atmosphere

2.1: 1H-tetrazole / dichloromethane; acetonitrile / 0.5 h / -40 - 20 °C / Inert atmosphere

3.1: dichloromethane; acetonitrile / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve

3.2: 2 h / -40 °C / Inert atmosphere

4.1: pyridine / 20 °C / Inert atmosphere

With pyridine; 1H-tetrazole; N-Bromosuccinimide; water; In dichloromethane; water; acetone; acetonitrile;
DOI:10.1016/j.tetlet.2012.08.077

Reference yield:

: 374573-40-7
(2S,4S,5R,6R)-5-Amino-4-hydroxy-2-p-tolylsulfanyl-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 1071226-23-7
p-tolyl (methyl 4,7,8,9-tetra-O-acetyl-3,5-dideoxy-5-trichloroacetamido-D-glycero-α-D-galacto-2-nonulopyranosylonate-(2->3))-2-O-benzoyl-4,6-O-benzylidene-1-thio-β-D-galactopyranoside

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / methanol / 0 - 20 °C / Inert atmosphere

2.1: pyridine; dmap / 0 - 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide; water / acetone; water / 0 - 20 °C / Inert atmosphere

4.1: 1H-tetrazole / dichloromethane; acetonitrile / 0.5 h / -40 - 20 °C / Inert atmosphere

5.1: dichloromethane; acetonitrile / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve

5.2: 2 h / -40 °C / Inert atmosphere

6.1: pyridine / 20 °C / Inert atmosphere

With pyridine; 1H-tetrazole; dmap; N-Bromosuccinimide; water; triethylamine; In methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1016/j.tetlet.2012.08.077