methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate
CAS No.:1010801-01-0
Molecular Formula:C₁₃H₁₆F₂O₄
Molecular Weight:274.264
Hs Code.:

Synonyms:methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate

Suppliers and Price of methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate

There total 7 articles about methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: dimethylketene methyl tirimethylsilyl acetal

: 256417-11-5
2,3-difluoro-4-methoxy-benzaldehyde

: 1010801-01-0
methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.08.121

Reference yield:

: 31469-15-5
1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

: 256417-11-5
2,3-difluoro-4-methoxy-benzaldehyde

: 1010801-01-0
methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 749230-30-6
(2,3-difluorophenoxy)triisopropylsilane

: 1010801-01-0
methyl 3-(2,3-difluoro-4-methoxyphenyl)-3-hydroxy-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: borane-THF / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

2.2: 6 h / 60 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide; acetone / 5.5 h / 20 °C

5.1: boron trifluoride diethyl etherate / diethyl ether / 1 h / 20 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; borane-THF; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2012.08.121