N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide

Base Information

Chemical Name:N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide
CAS No.:1563063-05-7
Molecular Formula:C₁₈H₁₈ClF₂NO₃S₂
Molecular Weight:433.928
Hs Code.:

Synonyms:N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide

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Chemical Property of N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide

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Technology Process of N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide

There total 5 articles about N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1563063-04-6
ethyl ({4-[(4-chlorophenyl)sulfanyl]-4,4-difluoro-1-[N-(4-methoxyphenyl)methanesulfonamido]butan-2-yl}sulfanyl)methanethioate

: 1563063-05-7
N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide

: 1563063-08-0
C₁₈H₁₈ClF₂NO₃S₂

Guidance literature:: ethyl ({4-[(4-chlorophenyl)sulfanyl]-4,4-difluoro-1-[N-(4-methoxyphenyl)methanesulfonamido]butan-2-yl}sulfanyl)methanethioate; In ethyl acetate; for 0.25h; Reflux; Inert atmosphere;

With dilauryl peroxide; In ethyl acetate; Inert atmosphere;
DOI:10.1021/ol5002939

Reference yield:

: 18803-44-6
sodium p-chlorothiophenolate

: 1563063-05-7
N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide

: 1563063-08-0
C₁₈H₁₈ClF₂NO₃S₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane / 4 h / Reflux; Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / Inert atmosphere

3.1: 1,4-dioxane; dichloromethane; cyclohexane / 6 h / 0 °C / Inert atmosphere

3.2: 12 h / Irradiation; Reflux; Inert atmosphere

4.1: ethyl acetate / 0.25 h / Inert atmosphere; Reflux

4.2: Inert atmosphere

5.1: ethyl acetate / 0.25 h / Reflux; Inert atmosphere

5.2: Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; cyclohexane; ethyl acetate;
DOI:10.1021/ol5002939

Reference yield:

: 16503-81-4
2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid

: 1563063-05-7
N-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-N-(4-methoxyphenyl)methanesulfonamide

: 1563063-08-0
C₁₈H₁₈ClF₂NO₃S₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / Inert atmosphere

2.1: 1,4-dioxane; dichloromethane; cyclohexane / 6 h / 0 °C / Inert atmosphere

2.2: 12 h / Irradiation; Reflux; Inert atmosphere

3.1: ethyl acetate / 0.25 h / Inert atmosphere; Reflux

3.2: Inert atmosphere

4.1: ethyl acetate / 0.25 h / Reflux; Inert atmosphere

4.2: Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; cyclohexane; ethyl acetate;
DOI:10.1021/ol5002939