2-{2'-[(3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-sulfamoyl]-4-oxazol-2-yl-biphenyl-2-yl}-N,N-dimethyl-acetamide

Base Information

• Chemical Name: 2-{2'-[(3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-sulfamoyl]-4-oxazol-2-yl-biphenyl-2-yl}-N,N-dimethyl-acetamide
• CAS No.: 195447-16-6
• Molecular Formula: C₂₈H₃₂N₄O₇S
• Molecular Weight: 568.651
• Mol file: 195447-16-6.mol

Synonyms:2-{2'-[(3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-sulfamoyl]-4-oxazol-2-yl-biphenyl-2-yl}-N,N-dimethyl-acetamide

Chemical Property of 2-{2'-[(3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-sulfamoyl]-4-oxazol-2-yl-biphenyl-2-yl}-N,N-dimethyl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2'-[(3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-sulfamoyl]-4-oxazol-2-yl-biphenyl-2-yl}-N,N-dimethyl-acetamide

There total 5 articles about 2-{2'-[(3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-sulfamoyl]-4-oxazol-2-yl-biphenyl-2-yl}-N,N-dimethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3,4-Dimethyl-5-isoxazolyl)-2'-formyl-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)-[1,1'-biphenyl]-2-sulfonamide (176961-44-7) → 2-{2'-[(3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-sulfamoyl]-4-oxazol-2-yl-biphenyl-2-yl}-N,N-dimethyl-acetamide (195447-16-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran; nitromethane / 0.33 h / 0 °C

1.2: tetrahydrofuran; cyclohexane / 1 h / 20 °C

2.1: 63 percent / p-TsOH / dioxane; H₂O / 4 h / Heating

3.1: sulfamic acid; aq. sodium chlorite / tetrahydrofuran / 0.03 h / 0 °C

4.1: (COCl)2 / dimethylformamide; CH₂Cl₂ / 1 h

5.1: tetrahydrofuran; H₂O / 1 h / 20 °C

With sodium chlorite; oxalyl dichloride; aminosulfonic acid; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; nitromethane; dichloromethane; water; N,N-dimethyl-formamide; 1.2: Wittig reaction;

DOI:10.1021/jm020289q

Reference yield:

N-(3,4-dimethyl-5-isoxazolyl)-2'-(formylmethyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)-[1,1'-biphenyl]-2-sulfonamide (195447-13-3) → 2-{2'-[(3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-sulfamoyl]-4-oxazol-2-yl-biphenyl-2-yl}-N,N-dimethyl-acetamide (195447-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfamic acid; aq. sodium chlorite / tetrahydrofuran / 0.03 h / 0 °C

2: (COCl)2 / dimethylformamide; CH₂Cl₂ / 1 h

3: tetrahydrofuran; H₂O / 1 h / 20 °C

With sodium chlorite; oxalyl dichloride; aminosulfonic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm020289q

Reference yield:

4'-oxazol-2-yl-2'-vinyl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-amide → 2-{2'-[(3,4-dimethyl-isoxazol-5-yl)-(2-methoxy-ethoxymethyl)-sulfamoyl]-4-oxazol-2-yl-biphenyl-2-yl}-N,N-dimethyl-acetamide (195447-16-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 63 percent / p-TsOH / dioxane; H₂O / 4 h / Heating

2: sulfamic acid; aq. sodium chlorite / tetrahydrofuran / 0.03 h / 0 °C

3: (COCl)2 / dimethylformamide; CH₂Cl₂ / 1 h

4: tetrahydrofuran; H₂O / 1 h / 20 °C

With sodium chlorite; oxalyl dichloride; aminosulfonic acid; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm020289q

upstream raw materials:

dimethyl amine

N-(3,4-Dimethyl-5-isoxazolyl)-2'-formyl-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)-[1,1'-biphenyl]-2-sulfonamide

N-(3,4-dimethyl-5-isoxazolyl)-2'-(formylmethyl)-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)-[1,1'-biphenyl]-2-sulfonamide

2'-[[(3,4-Dimethyl-5-isoxazolyl)[(2-methoxyethoxy)methyl]amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-acetic acid